Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia
Abstract This study determined the prevalence of total hepatitis A antibody (anti-HAV) among 5–7 years old children and their mothers in the whole Cambodia, using a nationwide study, and examined the differences between the two cohorts. A total of 4535 dried blood spot-driven (DBS) samples (2021 mot...
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Nature Portfolio
2021
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oai:doaj.org-article:58293f29ef8f4732baef2f19b30e39be2021-12-02T13:34:58ZPrevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia10.1038/s41598-021-83710-22045-2322https://doaj.org/article/58293f29ef8f4732baef2f19b30e39be2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83710-2https://doaj.org/toc/2045-2322Abstract This study determined the prevalence of total hepatitis A antibody (anti-HAV) among 5–7 years old children and their mothers in the whole Cambodia, using a nationwide study, and examined the differences between the two cohorts. A total of 4535 dried blood spot-driven (DBS) samples (2021 mothers and their 2514 children of 5–7 years old) and the concomitant 922 whole blood samples (subset of the whole participants) were collected using a multistage random sampling strategy throughout Cambodia in 2017. Total anti-HAV was detected using the chemiluminescence enzyme immunoassay method. Compared to gold standard whole blood samples, the sensitivity and specificity of DBS mediated anti-HAV detection were 94.8% and 98%, respectively. Total anti-HAV prevalence among mothers was 91.2% (95%CI: 90.0–92.5%), and that of their children was 31.5% (95%CI: 29.7–33.3%). In our study, the low prevalence of total anti-HAV among children indicates the country’s improvement of safe water and food supply, hygiene and sanitation. If the hygiene and sanitation are consistently improved in Cambodia, the prevalence might be no longer increased when the children become adults.Shintaro NagashimaKo KoChikako YamamotoE. BunthenSerge OuobaChannarena ChuonMasayuki OhisaAya SugiyamaTomoyuki AkitaMd. Shafiqul HossainVichit OrkBunsoth MaoJunko TanakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Shintaro Nagashima Ko Ko Chikako Yamamoto E. Bunthen Serge Ouoba Channarena Chuon Masayuki Ohisa Aya Sugiyama Tomoyuki Akita Md. Shafiqul Hossain Vichit Ork Bunsoth Mao Junko Tanaka Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
| description |
Abstract This study determined the prevalence of total hepatitis A antibody (anti-HAV) among 5–7 years old children and their mothers in the whole Cambodia, using a nationwide study, and examined the differences between the two cohorts. A total of 4535 dried blood spot-driven (DBS) samples (2021 mothers and their 2514 children of 5–7 years old) and the concomitant 922 whole blood samples (subset of the whole participants) were collected using a multistage random sampling strategy throughout Cambodia in 2017. Total anti-HAV was detected using the chemiluminescence enzyme immunoassay method. Compared to gold standard whole blood samples, the sensitivity and specificity of DBS mediated anti-HAV detection were 94.8% and 98%, respectively. Total anti-HAV prevalence among mothers was 91.2% (95%CI: 90.0–92.5%), and that of their children was 31.5% (95%CI: 29.7–33.3%). In our study, the low prevalence of total anti-HAV among children indicates the country’s improvement of safe water and food supply, hygiene and sanitation. If the hygiene and sanitation are consistently improved in Cambodia, the prevalence might be no longer increased when the children become adults. |
| format |
article |
| author |
Shintaro Nagashima Ko Ko Chikako Yamamoto E. Bunthen Serge Ouoba Channarena Chuon Masayuki Ohisa Aya Sugiyama Tomoyuki Akita Md. Shafiqul Hossain Vichit Ork Bunsoth Mao Junko Tanaka |
| author_facet |
Shintaro Nagashima Ko Ko Chikako Yamamoto E. Bunthen Serge Ouoba Channarena Chuon Masayuki Ohisa Aya Sugiyama Tomoyuki Akita Md. Shafiqul Hossain Vichit Ork Bunsoth Mao Junko Tanaka |
| author_sort |
Shintaro Nagashima |
| title |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
| title_short |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
| title_full |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
| title_fullStr |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
| title_full_unstemmed |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
| title_sort |
prevalence of total hepatitis a antibody among 5 to 7 years old children and their mothers in cambodia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/58293f29ef8f4732baef2f19b30e39be |
| work_keys_str_mv |
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