Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation

Hsiao-Wei Wang1, Chung-Wei Cheng2, Ching-Wen Li3, Han-Wei Chang4, Ping-Han Wu2, Gou-Jen Wang&nbsp;1Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, 2Laser Application Technology Center, Industrial Technology Research Institute, Tainan County, T...

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Autores principales:	Wang GJ, Wu PH, Chang HW, Li CW, Cheng CW, Wang HW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/582d898046714e1d8a5be6a2197a2afc
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spelling	oai:doaj.org-article:582d898046714e1d8a5be6a2197a2afc2021-12-02T07:14:17ZFabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation1176-91141178-2013https://doaj.org/article/582d898046714e1d8a5be6a2197a2afc2012-04-01T00:00:00Zhttp://www.dovepress.com/fabrication-of-pillared-plga-microvessel-scaffold-using-femtosecond-la-a9649https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hsiao-Wei Wang1, Chung-Wei Cheng2, Ching-Wen Li3, Han-Wei Chang4, Ping-Han Wu2, Gou-Jen Wang&nbsp;1Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, 2Laser Application Technology Center, Industrial Technology Research Institute, Tainan County, Taiwan, 3Department of Mechanical Engineering, 4Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, People&rsquo;s Republic of ChinaAbstract: One of the persistent challenges confronting tissue engineering is the lack of intrinsic microvessels for the transportation of nutrients and metabolites. An artificial microvascular system could be a feasible solution to this problem. In this study, the femtosecond laser ablation technique was implemented for the fabrication of pillared microvessel scaffolds of polylactic-co-glycolic acid (PLGA). This novel scaffold facilitates implementation of the conventional cell seeding process. The progress of cell growth can be observed in vitro by optical microscopy. The problems of becoming milky or completely opaque with the conventional PLGA scaffold after cell seeding can be resolved. In this study, PLGA microvessel scaffolds consisting of 47 &micro;m &times; 80 &micro;m pillared branches were produced. Results of cell culturing of bovine endothelial cells demonstrate that the cells adhere well and grow to surround each branch of the proposed pillared microvessel networks.Keywords: femtosecond laser ablation, pillared microvessel scaffold, polylactic-co-glycolic acid, bovine endothelial cellsWang GJWu PHChang HWLi CWCheng CWWang HWDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1865-1873 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang GJ Wu PH Chang HW Li CW Cheng CW Wang HW Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
description	Hsiao-Wei Wang1, Chung-Wei Cheng2, Ching-Wen Li3, Han-Wei Chang4, Ping-Han Wu2, Gou-Jen Wang&nbsp;1Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, 2Laser Application Technology Center, Industrial Technology Research Institute, Tainan County, Taiwan, 3Department of Mechanical Engineering, 4Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, People&rsquo;s Republic of ChinaAbstract: One of the persistent challenges confronting tissue engineering is the lack of intrinsic microvessels for the transportation of nutrients and metabolites. An artificial microvascular system could be a feasible solution to this problem. In this study, the femtosecond laser ablation technique was implemented for the fabrication of pillared microvessel scaffolds of polylactic-co-glycolic acid (PLGA). This novel scaffold facilitates implementation of the conventional cell seeding process. The progress of cell growth can be observed in vitro by optical microscopy. The problems of becoming milky or completely opaque with the conventional PLGA scaffold after cell seeding can be resolved. In this study, PLGA microvessel scaffolds consisting of 47 &micro;m &times; 80 &micro;m pillared branches were produced. Results of cell culturing of bovine endothelial cells demonstrate that the cells adhere well and grow to surround each branch of the proposed pillared microvessel networks.Keywords: femtosecond laser ablation, pillared microvessel scaffold, polylactic-co-glycolic acid, bovine endothelial cells
format	article
author	Wang GJ Wu PH Chang HW Li CW Cheng CW Wang HW
author_facet	Wang GJ Wu PH Chang HW Li CW Cheng CW Wang HW
author_sort	Wang GJ
title	Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
title_short	Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
title_full	Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
title_fullStr	Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
title_full_unstemmed	Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
title_sort	fabrication of pillared plga microvessel scaffold using femtosecond laser ablation
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/582d898046714e1d8a5be6a2197a2afc
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_version_	1718399515886616576

Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation

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