Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis

Chlamydiae replicate in host cells within specialised vacuoles (inclusions), which are eventually ruptured to liberate the bacteria, leading to cell lysis. Here, Kerret al. use a laser ablation technique and videomicroscopy to show that inclusion rupture triggers a necrotic pathway in the host cell.

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Autores principales:	Markus C. Kerr, Guillermo A. Gomez, Charles Ferguson, Maria C. Tanzer, James M. Murphy, Alpha S. Yap, Robert G. Parton, Wilhelmina M. Huston, Rohan D Teasdale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5830fce444594ccebf7060c3ecb75ba5
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spelling	oai:doaj.org-article:5830fce444594ccebf7060c3ecb75ba52021-12-02T15:38:39ZLaser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis10.1038/ncomms147292041-1723https://doaj.org/article/5830fce444594ccebf7060c3ecb75ba52017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14729https://doaj.org/toc/2041-1723Chlamydiae replicate in host cells within specialised vacuoles (inclusions), which are eventually ruptured to liberate the bacteria, leading to cell lysis. Here, Kerret al. use a laser ablation technique and videomicroscopy to show that inclusion rupture triggers a necrotic pathway in the host cell.Markus C. KerrGuillermo A. GomezCharles FergusonMaria C. TanzerJames M. MurphyAlpha S. YapRobert G. PartonWilhelmina M. HustonRohan D TeasdaleNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Markus C. Kerr Guillermo A. Gomez Charles Ferguson Maria C. Tanzer James M. Murphy Alpha S. Yap Robert G. Parton Wilhelmina M. Huston Rohan D Teasdale Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
description	Chlamydiae replicate in host cells within specialised vacuoles (inclusions), which are eventually ruptured to liberate the bacteria, leading to cell lysis. Here, Kerret al. use a laser ablation technique and videomicroscopy to show that inclusion rupture triggers a necrotic pathway in the host cell.
format	article
author	Markus C. Kerr Guillermo A. Gomez Charles Ferguson Maria C. Tanzer James M. Murphy Alpha S. Yap Robert G. Parton Wilhelmina M. Huston Rohan D Teasdale
author_facet	Markus C. Kerr Guillermo A. Gomez Charles Ferguson Maria C. Tanzer James M. Murphy Alpha S. Yap Robert G. Parton Wilhelmina M. Huston Rohan D Teasdale
author_sort	Markus C. Kerr
title	Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
title_short	Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
title_full	Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
title_fullStr	Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
title_full_unstemmed	Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
title_sort	laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5830fce444594ccebf7060c3ecb75ba5
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Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis

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