HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by tox...

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Autores principales:	Sarah Kishinevsky, Tai Wang, Anna Rodina, Sun Young Chung, Chao Xu, John Philip, Tony Taldone, Suhasini Joshi, Mary L. Alpaugh, Alexander Bolaender, Simon Gutbier, Davinder Sandhu, Faranak Fattahi, Bastian Zimmer, Smit K. Shah, Elizabeth Chang, Carmen Inda, John Koren, Nathalie G. Saurat, Marcel Leist, Steven S. Gross, Venkatraman E. Seshan, Christine Klein, Mark J. Tomishima, Hediye Erdjument-Bromage, Thomas A. Neubert, Ronald C. Henrickson, Gabriela Chiosis, Lorenz Studer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58327b67c3514927a9a253f4bd3c8f1f
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id	oai:doaj.org-article:58327b67c3514927a9a253f4bd3c8f1f
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spelling	oai:doaj.org-article:58327b67c3514927a9a253f4bd3c8f1f2021-12-02T15:34:01ZHSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons10.1038/s41467-018-06486-62041-1723https://doaj.org/article/58327b67c3514927a9a253f4bd3c8f1f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06486-6https://doaj.org/toc/2041-1723The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by toxic and genetic stresses that mimic those occurring during neurodegeneration.Sarah KishinevskyTai WangAnna RodinaSun Young ChungChao XuJohn PhilipTony TaldoneSuhasini JoshiMary L. AlpaughAlexander BolaenderSimon GutbierDavinder SandhuFaranak FattahiBastian ZimmerSmit K. ShahElizabeth ChangCarmen IndaJohn KorenNathalie G. SauratMarcel LeistSteven S. GrossVenkatraman E. SeshanChristine KleinMark J. TomishimaHediye Erdjument-BromageThomas A. NeubertRonald C. HenricksonGabriela ChiosisLorenz StuderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Kishinevsky Tai Wang Anna Rodina Sun Young Chung Chao Xu John Philip Tony Taldone Suhasini Joshi Mary L. Alpaugh Alexander Bolaender Simon Gutbier Davinder Sandhu Faranak Fattahi Bastian Zimmer Smit K. Shah Elizabeth Chang Carmen Inda John Koren Nathalie G. Saurat Marcel Leist Steven S. Gross Venkatraman E. Seshan Christine Klein Mark J. Tomishima Hediye Erdjument-Bromage Thomas A. Neubert Ronald C. Henrickson Gabriela Chiosis Lorenz Studer HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
description	The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by toxic and genetic stresses that mimic those occurring during neurodegeneration.
format	article
author	Sarah Kishinevsky Tai Wang Anna Rodina Sun Young Chung Chao Xu John Philip Tony Taldone Suhasini Joshi Mary L. Alpaugh Alexander Bolaender Simon Gutbier Davinder Sandhu Faranak Fattahi Bastian Zimmer Smit K. Shah Elizabeth Chang Carmen Inda John Koren Nathalie G. Saurat Marcel Leist Steven S. Gross Venkatraman E. Seshan Christine Klein Mark J. Tomishima Hediye Erdjument-Bromage Thomas A. Neubert Ronald C. Henrickson Gabriela Chiosis Lorenz Studer
author_facet	Sarah Kishinevsky Tai Wang Anna Rodina Sun Young Chung Chao Xu John Philip Tony Taldone Suhasini Joshi Mary L. Alpaugh Alexander Bolaender Simon Gutbier Davinder Sandhu Faranak Fattahi Bastian Zimmer Smit K. Shah Elizabeth Chang Carmen Inda John Koren Nathalie G. Saurat Marcel Leist Steven S. Gross Venkatraman E. Seshan Christine Klein Mark J. Tomishima Hediye Erdjument-Bromage Thomas A. Neubert Ronald C. Henrickson Gabriela Chiosis Lorenz Studer
author_sort	Sarah Kishinevsky
title	HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
title_short	HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
title_full	HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
title_fullStr	HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
title_full_unstemmed	HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
title_sort	hsp90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/58327b67c3514927a9a253f4bd3c8f1f
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HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

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