A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.

Magnetic nanoparticles (MNPs) of Fe(3)O(4) have been widely applied in many medical fields, but few studies have clearly shown the outcome of particles following intravenous injection. We performed a magnetic examination using scanning SQUID biosusceptometry (SSB). Based on the results of SSB analys...

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Autores principales:	Wei-Kung Tseng, Jen-Jie Chieh, Yi-Fan Yang, Chih-Kang Chiang, Yuh-Lien Chen, Shieh Yueh Yang, Herng-Er Horng, Hong-Chang Yang, Chau-Chung Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5832836cf10149779595f39420bd86ab
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spelling	oai:doaj.org-article:5832836cf10149779595f39420bd86ab2021-11-18T08:09:10ZA noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.1932-620310.1371/journal.pone.0048510https://doaj.org/article/5832836cf10149779595f39420bd86ab2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23152779/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Magnetic nanoparticles (MNPs) of Fe(3)O(4) have been widely applied in many medical fields, but few studies have clearly shown the outcome of particles following intravenous injection. We performed a magnetic examination using scanning SQUID biosusceptometry (SSB). Based on the results of SSB analysis and those of established in vitro nonmagnetic bioassays, this study proposes a model of MNP metabolism consisting of an acute metabolic phase with an 8 h duration that is followed by a chronic metabolic phase that continues for 28 d following MNP injection. The major features included the delivery of the MNPs to the heart and other organs, the biodegradation of the MNPs in organs rich with macrophages, the excretion of iron metabolites in the urine, and the recovery of the iron load from the liver and the spleen. Increases in serum iron levels following MNP injection were accompanied by increases in the level of transferrin in the serum and the number of circulating red blood cells. Correlations between the in vivo and in vitro test results indicate the feasibility of using SSB examination for the measurement of MNP concentrations, implying future clinical applications of SSB for monitoring the hematological effects of MNP injection.Wei-Kung TsengJen-Jie ChiehYi-Fan YangChih-Kang ChiangYuh-Lien ChenShieh Yueh YangHerng-Er HorngHong-Chang YangChau-Chung WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48510 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-Kung Tseng Jen-Jie Chieh Yi-Fan Yang Chih-Kang Chiang Yuh-Lien Chen Shieh Yueh Yang Herng-Er Horng Hong-Chang Yang Chau-Chung Wu A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.
description	Magnetic nanoparticles (MNPs) of Fe(3)O(4) have been widely applied in many medical fields, but few studies have clearly shown the outcome of particles following intravenous injection. We performed a magnetic examination using scanning SQUID biosusceptometry (SSB). Based on the results of SSB analysis and those of established in vitro nonmagnetic bioassays, this study proposes a model of MNP metabolism consisting of an acute metabolic phase with an 8 h duration that is followed by a chronic metabolic phase that continues for 28 d following MNP injection. The major features included the delivery of the MNPs to the heart and other organs, the biodegradation of the MNPs in organs rich with macrophages, the excretion of iron metabolites in the urine, and the recovery of the iron load from the liver and the spleen. Increases in serum iron levels following MNP injection were accompanied by increases in the level of transferrin in the serum and the number of circulating red blood cells. Correlations between the in vivo and in vitro test results indicate the feasibility of using SSB examination for the measurement of MNP concentrations, implying future clinical applications of SSB for monitoring the hematological effects of MNP injection.
format	article
author	Wei-Kung Tseng Jen-Jie Chieh Yi-Fan Yang Chih-Kang Chiang Yuh-Lien Chen Shieh Yueh Yang Herng-Er Horng Hong-Chang Yang Chau-Chung Wu
author_facet	Wei-Kung Tseng Jen-Jie Chieh Yi-Fan Yang Chih-Kang Chiang Yuh-Lien Chen Shieh Yueh Yang Herng-Er Horng Hong-Chang Yang Chau-Chung Wu
author_sort	Wei-Kung Tseng
title	A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.
title_short	A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.
title_full	A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.
title_fullStr	A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.
title_full_unstemmed	A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.
title_sort	noninvasive method to determine the fate of fe(3)o(4) nanoparticles following intravenous injection using scanning squid biosusceptometry.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5832836cf10149779595f39420bd86ab
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A noninvasive method to determine the fate of Fe(3)O(4) nanoparticles following intravenous injection using scanning SQUID biosusceptometry.

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