HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME

Retrospective research of 381 clinical records is conducted to study HIV infection influence on stationary stage of tuberculosis treatment outcome in HIV-TB co-infected patients. All cases were divided depending on a hospitalization outcome on favorable and adverse. At most of patients tuberculosis...

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Autores principales:	A. V. Mordyk, S. V. Sitnikova, L. V. Puzyreva
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	tuberculosis hiv infection efficiency of treatment tuberculosis at hiv-positive people Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5832d7e78f11417cb0295433ae3e24b4
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spelling	oai:doaj.org-article:5832d7e78f11417cb0295433ae3e24b42021-11-22T07:09:47ZHIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME2220-76192313-739810.15789/2220-7619-2016-1-81-86https://doaj.org/article/5832d7e78f11417cb0295433ae3e24b42016-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/388https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Retrospective research of 381 clinical records is conducted to study HIV infection influence on stationary stage of tuberculosis treatment outcome in HIV-TB co-infected patients. All cases were divided depending on a hospitalization outcome on favorable and adverse. At most of patients tuberculosis of respiratory organs met. Immunological researches were conducted, the stage of HIV infection was registered and the issue of purpose of anti-retroviral therapy was resolved. Besides, as indirect signs of an immunodeficiency at the patients with a combination of tuberculosis and HIV infection who were on hospitalization the indicators received when carrying out clinical laboratory trials were analyzed: absolute and relative quantity of lymphocytes according to the general blood test, the contents the globulin fractions and circulating immune complexes concentration according to the clinical chemistry blood test. At an assessment of results in both groups of research more than at a half of patients existence of HIV infection at late stages that speaks about late identification and neglect of an immunodeficiency was revealed. At patients with tuberculosis of lungs in combination with HIV infection at a failure statistically significant decrease in an immunoregulatory index is revealed. It is interesting that the level of CD4 lymphocytes and a stage of HIV infection had no impact on the co-infection’s outcome. However, existence of virus loa ding more than 100 000 copies/ml reduced probability favorable an outcome of treatment of tuberculosis at the patient with HIV infection. Timely purpose of anti-retroviral therapy at patients with co-infection increased chances of treatment of tuberculosis at patients with an immunodeficiency. Frequency of adverse side effect of antiviral therapy met equally often at patients in both groups. Thus, patients at any stages of HIV infection with any forms of tuberculosis, including generalized, had a chance to have a favorable outcome of a disease. We consider the reasonable recommendation about carrying out anti-retroviral therapy of patients by all with a combination of tuberculosis and HIV infection, irrespective of the HIV infection stage.A. V. MordykS. V. SitnikovaL. V. PuzyrevaSankt-Peterburg : NIIÈM imeni Pasteraarticletuberculosishiv infectionefficiency of treatmenttuberculosis at hiv-positive peopleInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 1, Pp 81-86 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis hiv infection efficiency of treatment tuberculosis at hiv-positive people Infectious and parasitic diseases RC109-216
spellingShingle	tuberculosis hiv infection efficiency of treatment tuberculosis at hiv-positive people Infectious and parasitic diseases RC109-216 A. V. Mordyk S. V. Sitnikova L. V. Puzyreva HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME
description	Retrospective research of 381 clinical records is conducted to study HIV infection influence on stationary stage of tuberculosis treatment outcome in HIV-TB co-infected patients. All cases were divided depending on a hospitalization outcome on favorable and adverse. At most of patients tuberculosis of respiratory organs met. Immunological researches were conducted, the stage of HIV infection was registered and the issue of purpose of anti-retroviral therapy was resolved. Besides, as indirect signs of an immunodeficiency at the patients with a combination of tuberculosis and HIV infection who were on hospitalization the indicators received when carrying out clinical laboratory trials were analyzed: absolute and relative quantity of lymphocytes according to the general blood test, the contents the globulin fractions and circulating immune complexes concentration according to the clinical chemistry blood test. At an assessment of results in both groups of research more than at a half of patients existence of HIV infection at late stages that speaks about late identification and neglect of an immunodeficiency was revealed. At patients with tuberculosis of lungs in combination with HIV infection at a failure statistically significant decrease in an immunoregulatory index is revealed. It is interesting that the level of CD4 lymphocytes and a stage of HIV infection had no impact on the co-infection’s outcome. However, existence of virus loa ding more than 100 000 copies/ml reduced probability favorable an outcome of treatment of tuberculosis at the patient with HIV infection. Timely purpose of anti-retroviral therapy at patients with co-infection increased chances of treatment of tuberculosis at patients with an immunodeficiency. Frequency of adverse side effect of antiviral therapy met equally often at patients in both groups. Thus, patients at any stages of HIV infection with any forms of tuberculosis, including generalized, had a chance to have a favorable outcome of a disease. We consider the reasonable recommendation about carrying out anti-retroviral therapy of patients by all with a combination of tuberculosis and HIV infection, irrespective of the HIV infection stage.
format	article
author	A. V. Mordyk S. V. Sitnikova L. V. Puzyreva
author_facet	A. V. Mordyk S. V. Sitnikova L. V. Puzyreva
author_sort	A. V. Mordyk
title	HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME
title_short	HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME
title_full	HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME
title_fullStr	HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME
title_full_unstemmed	HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME
title_sort	hiv infection stage, antiretroviral therapy scheme and patient immune status influence on hiv/tb co-infection outcome
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/5832d7e78f11417cb0295433ae3e24b4
work_keys_str_mv	AT avmordyk hivinfectionstageantiretroviraltherapyschemeandpatientimmunestatusinfluenceonhivtbcoinfectionoutcome AT svsitnikova hivinfectionstageantiretroviraltherapyschemeandpatientimmunestatusinfluenceonhivtbcoinfectionoutcome AT lvpuzyreva hivinfectionstageantiretroviraltherapyschemeandpatientimmunestatusinfluenceonhivtbcoinfectionoutcome
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HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME

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