Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification

The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promoting chromatin opening at epidermal gene enhancers...

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Autores principales: José M. Santos-Pereira, Lourdes Gallardo-Fuentes, Ana Neto, Rafael D. Acemel, Juan J. Tena
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/58356b9f31a8417baac5d84a98baac31
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Sumario:The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promoting chromatin opening at epidermal gene enhancers.