Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification

The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promoting chromatin opening at epidermal gene enhancers...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	José M. Santos-Pereira, Lourdes Gallardo-Fuentes, Ana Neto, Rafael D. Acemel, Juan J. Tena
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58356b9f31a8417baac5d84a98baac31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58356b9f31a8417baac5d84a98baac31
record_format	dspace
spelling	oai:doaj.org-article:58356b9f31a8417baac5d84a98baac312021-12-02T15:35:54ZPioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification10.1038/s41467-019-11121-z2041-1723https://doaj.org/article/58356b9f31a8417baac5d84a98baac312019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11121-zhttps://doaj.org/toc/2041-1723The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promoting chromatin opening at epidermal gene enhancers.José M. Santos-PereiraLourdes Gallardo-FuentesAna NetoRafael D. AcemelJuan J. TenaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q José M. Santos-Pereira Lourdes Gallardo-Fuentes Ana Neto Rafael D. Acemel Juan J. Tena Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
description	The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promoting chromatin opening at epidermal gene enhancers.
format	article
author	José M. Santos-Pereira Lourdes Gallardo-Fuentes Ana Neto Rafael D. Acemel Juan J. Tena
author_facet	José M. Santos-Pereira Lourdes Gallardo-Fuentes Ana Neto Rafael D. Acemel Juan J. Tena
author_sort	José M. Santos-Pereira
title	Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
title_short	Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
title_full	Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
title_fullStr	Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
title_full_unstemmed	Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
title_sort	pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/58356b9f31a8417baac5d84a98baac31
work_keys_str_mv	AT josemsantospereira pioneerandrepressivefunctionsofp63duringzebrafishembryonicectodermspecification AT lourdesgallardofuentes pioneerandrepressivefunctionsofp63duringzebrafishembryonicectodermspecification AT ananeto pioneerandrepressivefunctionsofp63duringzebrafishembryonicectodermspecification AT rafaeldacemel pioneerandrepressivefunctionsofp63duringzebrafishembryonicectodermspecification AT juanjtena pioneerandrepressivefunctionsofp63duringzebrafishembryonicectodermspecification
_version_	1718386411888967680

Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification

Ejemplares similares