Offline persistence of memory-related cerebral activity during active wakefulness.

Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, litt...

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Autores principales: Philippe Peigneux, Pierre Orban, Evelyne Balteau, Christian Degueldre, André Luxen, Steven Laureys, Pierre Maquet
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Publicado: Public Library of Science (PLoS) 2006
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spelling oai:doaj.org-article:583797d22e804df9882746834c763d982021-11-25T05:33:12ZOffline persistence of memory-related cerebral activity during active wakefulness.1544-91731545-788510.1371/journal.pbio.0040100https://doaj.org/article/583797d22e804df9882746834c763d982006-04-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.0040100https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functional connections with other brain regions are gradually established or reinforced. It also correlates with behavioral performance. These processes follow a different time course for hippocampus-dependent and hippocampus-independent memories. Our experimental approach allowed the characterization of the offline evolution of the cerebral correlates of recent memories, without the confounding effect of concurrent practice of the learned material. Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands.Philippe PeigneuxPierre OrbanEvelyne BalteauChristian DegueldreAndré LuxenSteven LaureysPierre MaquetPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 4, Iss 4, p e100 (2006)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Philippe Peigneux
Pierre Orban
Evelyne Balteau
Christian Degueldre
André Luxen
Steven Laureys
Pierre Maquet
Offline persistence of memory-related cerebral activity during active wakefulness.
description Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functional connections with other brain regions are gradually established or reinforced. It also correlates with behavioral performance. These processes follow a different time course for hippocampus-dependent and hippocampus-independent memories. Our experimental approach allowed the characterization of the offline evolution of the cerebral correlates of recent memories, without the confounding effect of concurrent practice of the learned material. Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands.
format article
author Philippe Peigneux
Pierre Orban
Evelyne Balteau
Christian Degueldre
André Luxen
Steven Laureys
Pierre Maquet
author_facet Philippe Peigneux
Pierre Orban
Evelyne Balteau
Christian Degueldre
André Luxen
Steven Laureys
Pierre Maquet
author_sort Philippe Peigneux
title Offline persistence of memory-related cerebral activity during active wakefulness.
title_short Offline persistence of memory-related cerebral activity during active wakefulness.
title_full Offline persistence of memory-related cerebral activity during active wakefulness.
title_fullStr Offline persistence of memory-related cerebral activity during active wakefulness.
title_full_unstemmed Offline persistence of memory-related cerebral activity during active wakefulness.
title_sort offline persistence of memory-related cerebral activity during active wakefulness.
publisher Public Library of Science (PLoS)
publishDate 2006
url https://doaj.org/article/583797d22e804df9882746834c763d98
work_keys_str_mv AT philippepeigneux offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
AT pierreorban offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
AT evelynebalteau offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
AT christiandegueldre offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
AT andreluxen offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
AT stevenlaureys offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
AT pierremaquet offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness
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