Offline persistence of memory-related cerebral activity during active wakefulness.
Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, litt...
Guardado en:
Autores principales: | , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2006
|
Materias: | |
Acceso en línea: | https://doaj.org/article/583797d22e804df9882746834c763d98 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:583797d22e804df9882746834c763d98 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:583797d22e804df9882746834c763d982021-11-25T05:33:12ZOffline persistence of memory-related cerebral activity during active wakefulness.1544-91731545-788510.1371/journal.pbio.0040100https://doaj.org/article/583797d22e804df9882746834c763d982006-04-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.0040100https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functional connections with other brain regions are gradually established or reinforced. It also correlates with behavioral performance. These processes follow a different time course for hippocampus-dependent and hippocampus-independent memories. Our experimental approach allowed the characterization of the offline evolution of the cerebral correlates of recent memories, without the confounding effect of concurrent practice of the learned material. Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands.Philippe PeigneuxPierre OrbanEvelyne BalteauChristian DegueldreAndré LuxenSteven LaureysPierre MaquetPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 4, Iss 4, p e100 (2006) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Philippe Peigneux Pierre Orban Evelyne Balteau Christian Degueldre André Luxen Steven Laureys Pierre Maquet Offline persistence of memory-related cerebral activity during active wakefulness. |
description |
Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functional connections with other brain regions are gradually established or reinforced. It also correlates with behavioral performance. These processes follow a different time course for hippocampus-dependent and hippocampus-independent memories. Our experimental approach allowed the characterization of the offline evolution of the cerebral correlates of recent memories, without the confounding effect of concurrent practice of the learned material. Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands. |
format |
article |
author |
Philippe Peigneux Pierre Orban Evelyne Balteau Christian Degueldre André Luxen Steven Laureys Pierre Maquet |
author_facet |
Philippe Peigneux Pierre Orban Evelyne Balteau Christian Degueldre André Luxen Steven Laureys Pierre Maquet |
author_sort |
Philippe Peigneux |
title |
Offline persistence of memory-related cerebral activity during active wakefulness. |
title_short |
Offline persistence of memory-related cerebral activity during active wakefulness. |
title_full |
Offline persistence of memory-related cerebral activity during active wakefulness. |
title_fullStr |
Offline persistence of memory-related cerebral activity during active wakefulness. |
title_full_unstemmed |
Offline persistence of memory-related cerebral activity during active wakefulness. |
title_sort |
offline persistence of memory-related cerebral activity during active wakefulness. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2006 |
url |
https://doaj.org/article/583797d22e804df9882746834c763d98 |
work_keys_str_mv |
AT philippepeigneux offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness AT pierreorban offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness AT evelynebalteau offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness AT christiandegueldre offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness AT andreluxen offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness AT stevenlaureys offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness AT pierremaquet offlinepersistenceofmemoryrelatedcerebralactivityduringactivewakefulness |
_version_ |
1718414637596147712 |