Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as...

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Autores principales: Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Marje Kasari, Merianne Mohamad, Christine Polte, Hiraku Takada, Karolis Vaitkevicius, Jörgen Johansson, Zoya Ignatova, Gemma C. Atkinson, Alex J. O’Neill, Vasili Hauryliuk, Daniel N. Wilson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
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Sumario:Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.

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