Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as...

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Autores principales: Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Marje Kasari, Merianne Mohamad, Christine Polte, Hiraku Takada, Karolis Vaitkevicius, Jörgen Johansson, Zoya Ignatova, Gemma C. Atkinson, Alex J. O’Neill, Vasili Hauryliuk, Daniel N. Wilson
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
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spelling oai:doaj.org-article:5839d6ab4dd34e3b9dd6b83dd05b0b332021-12-02T15:02:50ZStructural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens10.1038/s41467-021-23753-12041-1723https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b332021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23753-1https://doaj.org/toc/2041-1723Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.Caillan Crowe-McAuliffeVictoriia MurinaKathryn Jane TurnbullMarje KasariMerianne MohamadChristine PolteHiraku TakadaKarolis VaitkeviciusJörgen JohanssonZoya IgnatovaGemma C. AtkinsonAlex J. O’NeillVasili HauryliukDaniel N. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Caillan Crowe-McAuliffe
Victoriia Murina
Kathryn Jane Turnbull
Marje Kasari
Merianne Mohamad
Christine Polte
Hiraku Takada
Karolis Vaitkevicius
Jörgen Johansson
Zoya Ignatova
Gemma C. Atkinson
Alex J. O’Neill
Vasili Hauryliuk
Daniel N. Wilson
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
description Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.
format article
author Caillan Crowe-McAuliffe
Victoriia Murina
Kathryn Jane Turnbull
Marje Kasari
Merianne Mohamad
Christine Polte
Hiraku Takada
Karolis Vaitkevicius
Jörgen Johansson
Zoya Ignatova
Gemma C. Atkinson
Alex J. O’Neill
Vasili Hauryliuk
Daniel N. Wilson
author_facet Caillan Crowe-McAuliffe
Victoriia Murina
Kathryn Jane Turnbull
Marje Kasari
Merianne Mohamad
Christine Polte
Hiraku Takada
Karolis Vaitkevicius
Jörgen Johansson
Zoya Ignatova
Gemma C. Atkinson
Alex J. O’Neill
Vasili Hauryliuk
Daniel N. Wilson
author_sort Caillan Crowe-McAuliffe
title Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_short Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_full Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_fullStr Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_full_unstemmed Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_sort structural basis of abcf-mediated resistance to pleuromutilin, lincosamide, and streptogramin a antibiotics in gram-positive pathogens
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
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