Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as...

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Autores principales:	Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Marje Kasari, Merianne Mohamad, Christine Polte, Hiraku Takada, Karolis Vaitkevicius, Jörgen Johansson, Zoya Ignatova, Gemma C. Atkinson, Alex J. O’Neill, Vasili Hauryliuk, Daniel N. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
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spelling	oai:doaj.org-article:5839d6ab4dd34e3b9dd6b83dd05b0b332021-12-02T15:02:50ZStructural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens10.1038/s41467-021-23753-12041-1723https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b332021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23753-1https://doaj.org/toc/2041-1723Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.Caillan Crowe-McAuliffeVictoriia MurinaKathryn Jane TurnbullMarje KasariMerianne MohamadChristine PolteHiraku TakadaKarolis VaitkeviciusJörgen JohanssonZoya IgnatovaGemma C. AtkinsonAlex J. O’NeillVasili HauryliukDaniel N. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caillan Crowe-McAuliffe Victoriia Murina Kathryn Jane Turnbull Marje Kasari Merianne Mohamad Christine Polte Hiraku Takada Karolis Vaitkevicius Jörgen Johansson Zoya Ignatova Gemma C. Atkinson Alex J. O’Neill Vasili Hauryliuk Daniel N. Wilson Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
description	Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.
format	article
author	Caillan Crowe-McAuliffe Victoriia Murina Kathryn Jane Turnbull Marje Kasari Merianne Mohamad Christine Polte Hiraku Takada Karolis Vaitkevicius Jörgen Johansson Zoya Ignatova Gemma C. Atkinson Alex J. O’Neill Vasili Hauryliuk Daniel N. Wilson
author_facet	Caillan Crowe-McAuliffe Victoriia Murina Kathryn Jane Turnbull Marje Kasari Merianne Mohamad Christine Polte Hiraku Takada Karolis Vaitkevicius Jörgen Johansson Zoya Ignatova Gemma C. Atkinson Alex J. O’Neill Vasili Hauryliuk Daniel N. Wilson
author_sort	Caillan Crowe-McAuliffe
title	Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_short	Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_full	Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_fullStr	Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_full_unstemmed	Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
title_sort	structural basis of abcf-mediated resistance to pleuromutilin, lincosamide, and streptogramin a antibiotics in gram-positive pathogens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
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Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

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