Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as...
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2021
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oai:doaj.org-article:5839d6ab4dd34e3b9dd6b83dd05b0b332021-12-02T15:02:50ZStructural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens10.1038/s41467-021-23753-12041-1723https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b332021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23753-1https://doaj.org/toc/2041-1723Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.Caillan Crowe-McAuliffeVictoriia MurinaKathryn Jane TurnbullMarje KasariMerianne MohamadChristine PolteHiraku TakadaKarolis VaitkeviciusJörgen JohanssonZoya IgnatovaGemma C. AtkinsonAlex J. O’NeillVasili HauryliukDaniel N. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Caillan Crowe-McAuliffe Victoriia Murina Kathryn Jane Turnbull Marje Kasari Merianne Mohamad Christine Polte Hiraku Takada Karolis Vaitkevicius Jörgen Johansson Zoya Ignatova Gemma C. Atkinson Alex J. O’Neill Vasili Hauryliuk Daniel N. Wilson Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens |
description |
Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors. |
format |
article |
author |
Caillan Crowe-McAuliffe Victoriia Murina Kathryn Jane Turnbull Marje Kasari Merianne Mohamad Christine Polte Hiraku Takada Karolis Vaitkevicius Jörgen Johansson Zoya Ignatova Gemma C. Atkinson Alex J. O’Neill Vasili Hauryliuk Daniel N. Wilson |
author_facet |
Caillan Crowe-McAuliffe Victoriia Murina Kathryn Jane Turnbull Marje Kasari Merianne Mohamad Christine Polte Hiraku Takada Karolis Vaitkevicius Jörgen Johansson Zoya Ignatova Gemma C. Atkinson Alex J. O’Neill Vasili Hauryliuk Daniel N. Wilson |
author_sort |
Caillan Crowe-McAuliffe |
title |
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens |
title_short |
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens |
title_full |
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens |
title_fullStr |
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens |
title_full_unstemmed |
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens |
title_sort |
structural basis of abcf-mediated resistance to pleuromutilin, lincosamide, and streptogramin a antibiotics in gram-positive pathogens |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33 |
work_keys_str_mv |
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1718389077557903360 |