Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.

Intravoxel incoherent motion (IVIM) is a method that can provide quantitative information about perfusion in the human body, in vivo, and without contrast agent. Unfortunately, the IVIM perfusion parameter maps are known to be relatively noisy in the brain, in particular for the pseudo-diffusion coe...

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Autores principales:	Harri Merisaari, Christian Federau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5839ea542f3748a1ad270d48e94f3673
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spelling	oai:doaj.org-article:5839ea542f3748a1ad270d48e94f36732021-12-02T20:08:04ZSignal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.1932-620310.1371/journal.pone.0257545https://doaj.org/article/5839ea542f3748a1ad270d48e94f36732021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257545https://doaj.org/toc/1932-6203Intravoxel incoherent motion (IVIM) is a method that can provide quantitative information about perfusion in the human body, in vivo, and without contrast agent. Unfortunately, the IVIM perfusion parameter maps are known to be relatively noisy in the brain, in particular for the pseudo-diffusion coefficient, which might hinder its potential broader use in clinical applications. Therefore, we studied the conditions to produce optimal IVIM perfusion images in the brain. IVIM imaging was performed on a 3-Tesla clinical system in four healthy volunteers, with 16 b values 0, 10, 20, 40, 80, 110, 140, 170, 200, 300, 400, 500, 600, 700, 800, 900 s/mm2, repeated 20 times. We analyzed the noise characteristics of the trace images as a function of b-value, and the homogeneity of the IVIM parameter maps across number of averages and sub-sets of the acquired b values. We found two peaks of noise of the trace images as function of b value, one due to thermal noise at high b-value, and one due to physiological noise at low b-value. The selection of b value distribution was found to have higher impact on the homogeneity of the IVIM parameter maps than the number of averages. Based on evaluations, we suggest an optimal b value acquisition scheme for a 12 min scan as 0 (7), 20 (4), 140 (19), 300 (9), 500 (19), 700 (1), 800 (4), 900 (1) s/mm2.Harri MerisaariChristian FederauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257545 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harri Merisaari Christian Federau Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
description	Intravoxel incoherent motion (IVIM) is a method that can provide quantitative information about perfusion in the human body, in vivo, and without contrast agent. Unfortunately, the IVIM perfusion parameter maps are known to be relatively noisy in the brain, in particular for the pseudo-diffusion coefficient, which might hinder its potential broader use in clinical applications. Therefore, we studied the conditions to produce optimal IVIM perfusion images in the brain. IVIM imaging was performed on a 3-Tesla clinical system in four healthy volunteers, with 16 b values 0, 10, 20, 40, 80, 110, 140, 170, 200, 300, 400, 500, 600, 700, 800, 900 s/mm2, repeated 20 times. We analyzed the noise characteristics of the trace images as a function of b-value, and the homogeneity of the IVIM parameter maps across number of averages and sub-sets of the acquired b values. We found two peaks of noise of the trace images as function of b value, one due to thermal noise at high b-value, and one due to physiological noise at low b-value. The selection of b value distribution was found to have higher impact on the homogeneity of the IVIM parameter maps than the number of averages. Based on evaluations, we suggest an optimal b value acquisition scheme for a 12 min scan as 0 (7), 20 (4), 140 (19), 300 (9), 500 (19), 700 (1), 800 (4), 900 (1) s/mm2.
format	article
author	Harri Merisaari Christian Federau
author_facet	Harri Merisaari Christian Federau
author_sort	Harri Merisaari
title	Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
title_short	Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
title_full	Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
title_fullStr	Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
title_full_unstemmed	Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
title_sort	signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5839ea542f3748a1ad270d48e94f3673
work_keys_str_mv	AT harrimerisaari signaltonoiseandbvalueanalysisforoptimalintravoxelincoherentmotionimaginginthebrain AT christianfederau signaltonoiseandbvalueanalysisforoptimalintravoxelincoherentmotionimaginginthebrain
_version_	1718375241571368960

Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain.

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