Additive effect of linseed oil supplementation on the lipid profiles of older adults
Ana Paula A Avelino,1 Gláucia MM Oliveira,1 Célia CD Ferreira,2 Ronir R Luiz,3 Glorimar Rosa1,4 1Post-Graduate Program of Medicine-Cardiology, 2Department of Nutrition and Dietetics, 3Institute of Public Health Studies, 4Department of Nutrition and Dietetics, Josué...
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Dove Medical Press
2015
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oai:doaj.org-article:583c41139c0f49899df15b78cec6ccea2021-12-02T02:42:45ZAdditive effect of linseed oil supplementation on the lipid profiles of older adults1178-1998https://doaj.org/article/583c41139c0f49899df15b78cec6ccea2015-10-01T00:00:00Zhttps://www.dovepress.com/additive-effect-of-linseed-oil-supplementation-onnbspthe-lipid-profile-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ana Paula A Avelino,1 Gláucia MM Oliveira,1 Célia CD Ferreira,2 Ronir R Luiz,3 Glorimar Rosa1,4 1Post-Graduate Program of Medicine-Cardiology, 2Department of Nutrition and Dietetics, 3Institute of Public Health Studies, 4Department of Nutrition and Dietetics, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Background: Linseed oil has been investigated as a rich source of n-3 series polyunsaturated fatty acids, which mainly produce a non-atherogenic lipid profile. The objective of this study was to investigate the effect of linseed oil supplementation associated with nutritional guidelines on the lipid profiles of older adults, according to the intake of saturated fatty acids (SFA).Methods: We conducted a double-blind, placebo-controlled clinical trial with 110 older adults randomized in two groups: placebo and linseed oil. The linseed oil group received supplementation with 3 g of linseed oil. Both groups received nutritional guidance and were supplemented for 90 days with monthly blood collection for biochemical analysis. The dietary intake of saturated fat was subdivided into low (<7% SFA/day of the total energy value) and high consumption groups (>7% SFA/day of the total energy value).Results: Low SFA (<7% SFA/day of total energy value) consumption was associated with lower total cholesterol concentrations. However, we observed that the linseed oil group, including older adults who consumed >7% SFA/day, had a greater reduction in total cholesterol than the placebo group (P=0.020). The same was observed for low-density lipoprotein (LDL) cholesterol (P<0.050), suggesting an additive effect of linseed oil and diet. High-density lipoprotein (HDL) cholesterol concentrations were increased significantly in only the linseed group, suggesting that the nutritional intervention alone did not improve HDL cholesterol.Conclusion: The results suggest that the nutritional intervention was effective, but linseed oil showed notable effects by increasing the HDL cholesterol concentration. In addition, consumption of <7% SFA/day of the total energy value increased the effect of linseed oil, demonstrating the importance of reducing the consumption of saturated fat. Keywords: linseed oil, high-density lipoprotein cholesterol, older adults, atherosclerosis, saturated fatty acids, elderly Avelino APAOliveira GMMFerreira CCDLuiz RRRosa GDove Medical Pressarticlelinseed oilHDL cholesterololder adultsatherosclerosissaturated fatty acidselderly.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 1679-1685 (2015) |
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linseed oil HDL cholesterol older adults atherosclerosis saturated fatty acids elderly. Geriatrics RC952-954.6 |
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linseed oil HDL cholesterol older adults atherosclerosis saturated fatty acids elderly. Geriatrics RC952-954.6 Avelino APA Oliveira GMM Ferreira CCD Luiz RR Rosa G Additive effect of linseed oil supplementation on the lipid profiles of older adults |
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Ana Paula A Avelino,1 Gláucia MM Oliveira,1 Célia CD Ferreira,2 Ronir R Luiz,3 Glorimar Rosa1,4 1Post-Graduate Program of Medicine-Cardiology, 2Department of Nutrition and Dietetics, 3Institute of Public Health Studies, 4Department of Nutrition and Dietetics, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Background: Linseed oil has been investigated as a rich source of n-3 series polyunsaturated fatty acids, which mainly produce a non-atherogenic lipid profile. The objective of this study was to investigate the effect of linseed oil supplementation associated with nutritional guidelines on the lipid profiles of older adults, according to the intake of saturated fatty acids (SFA).Methods: We conducted a double-blind, placebo-controlled clinical trial with 110 older adults randomized in two groups: placebo and linseed oil. The linseed oil group received supplementation with 3 g of linseed oil. Both groups received nutritional guidance and were supplemented for 90 days with monthly blood collection for biochemical analysis. The dietary intake of saturated fat was subdivided into low (<7% SFA/day of the total energy value) and high consumption groups (>7% SFA/day of the total energy value).Results: Low SFA (<7% SFA/day of total energy value) consumption was associated with lower total cholesterol concentrations. However, we observed that the linseed oil group, including older adults who consumed >7% SFA/day, had a greater reduction in total cholesterol than the placebo group (P=0.020). The same was observed for low-density lipoprotein (LDL) cholesterol (P<0.050), suggesting an additive effect of linseed oil and diet. High-density lipoprotein (HDL) cholesterol concentrations were increased significantly in only the linseed group, suggesting that the nutritional intervention alone did not improve HDL cholesterol.Conclusion: The results suggest that the nutritional intervention was effective, but linseed oil showed notable effects by increasing the HDL cholesterol concentration. In addition, consumption of <7% SFA/day of the total energy value increased the effect of linseed oil, demonstrating the importance of reducing the consumption of saturated fat. Keywords: linseed oil, high-density lipoprotein cholesterol, older adults, atherosclerosis, saturated fatty acids, elderly |
| format |
article |
| author |
Avelino APA Oliveira GMM Ferreira CCD Luiz RR Rosa G |
| author_facet |
Avelino APA Oliveira GMM Ferreira CCD Luiz RR Rosa G |
| author_sort |
Avelino APA |
| title |
Additive effect of linseed oil supplementation on the lipid profiles of older adults |
| title_short |
Additive effect of linseed oil supplementation on the lipid profiles of older adults |
| title_full |
Additive effect of linseed oil supplementation on the lipid profiles of older adults |
| title_fullStr |
Additive effect of linseed oil supplementation on the lipid profiles of older adults |
| title_full_unstemmed |
Additive effect of linseed oil supplementation on the lipid profiles of older adults |
| title_sort |
additive effect of linseed oil supplementation on the lipid profiles of older adults |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/583c41139c0f49899df15b78cec6ccea |
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