RNA structure probing reveals the structural basis of Dicer binding and cleavage

RNA structure probing reveals the structural basis of Dicer binding and cleavage

Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.

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Detalles Bibliográficos
Autores principales: Qing-Jun Luo, Jinsong Zhang, Pan Li, Qing Wang, Yue Zhang, Biswajoy Roy-Chaudhuri, Jianpeng Xu, Mark A. Kay, Qiangfeng Cliff Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/583fc732877b412c963fcb1b0df984ec
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Sumario:Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.

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