RNA structure probing reveals the structural basis of Dicer binding and cleavage

Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.

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Autores principales:	Qing-Jun Luo, Jinsong Zhang, Pan Li, Qing Wang, Yue Zhang, Biswajoy Roy-Chaudhuri, Jianpeng Xu, Mark A. Kay, Qiangfeng Cliff Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/583fc732877b412c963fcb1b0df984ec
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spelling	oai:doaj.org-article:583fc732877b412c963fcb1b0df984ec2021-12-02T17:34:47ZRNA structure probing reveals the structural basis of Dicer binding and cleavage10.1038/s41467-021-23607-w2041-1723https://doaj.org/article/583fc732877b412c963fcb1b0df984ec2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23607-whttps://doaj.org/toc/2041-1723Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.Qing-Jun LuoJinsong ZhangPan LiQing WangYue ZhangBiswajoy Roy-ChaudhuriJianpeng XuMark A. KayQiangfeng Cliff ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing-Jun Luo Jinsong Zhang Pan Li Qing Wang Yue Zhang Biswajoy Roy-Chaudhuri Jianpeng Xu Mark A. Kay Qiangfeng Cliff Zhang RNA structure probing reveals the structural basis of Dicer binding and cleavage
description	Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.
format	article
author	Qing-Jun Luo Jinsong Zhang Pan Li Qing Wang Yue Zhang Biswajoy Roy-Chaudhuri Jianpeng Xu Mark A. Kay Qiangfeng Cliff Zhang
author_facet	Qing-Jun Luo Jinsong Zhang Pan Li Qing Wang Yue Zhang Biswajoy Roy-Chaudhuri Jianpeng Xu Mark A. Kay Qiangfeng Cliff Zhang
author_sort	Qing-Jun Luo
title	RNA structure probing reveals the structural basis of Dicer binding and cleavage
title_short	RNA structure probing reveals the structural basis of Dicer binding and cleavage
title_full	RNA structure probing reveals the structural basis of Dicer binding and cleavage
title_fullStr	RNA structure probing reveals the structural basis of Dicer binding and cleavage
title_full_unstemmed	RNA structure probing reveals the structural basis of Dicer binding and cleavage
title_sort	rna structure probing reveals the structural basis of dicer binding and cleavage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/583fc732877b412c963fcb1b0df984ec
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_version_	1718379940970233856

RNA structure probing reveals the structural basis of Dicer binding and cleavage

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