Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief

The article goes to describe clinical and pharmacological approaches to choosing a drug with an optimal efficacy/safety profile, providing the necessary analgesic effect in tension-type headache. TRPV1 brain receptors are considered the main action point of the mediator. Aim. The purpose of this...

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Autores principales:	Evgeniya V. Shikh, Evgeniy D. Khaytovich, Aleksandr V. Perkov
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	buprofen paracetamol fixed dose combination tension-type headache Medicine R
Acceso en línea:	https://doaj.org/article/584172845407419585c77fe5cd0ac8d6
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spelling	oai:doaj.org-article:584172845407419585c77fe5cd0ac8d62021-12-01T12:22:36ZClinical and pharmacological approaches to the choice of a drug for a tension-type headache relief0040-36602309-534210.26442/00403660.2021.08.200920https://doaj.org/article/584172845407419585c77fe5cd0ac8d62021-08-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/79413/60065https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342The article goes to describe clinical and pharmacological approaches to choosing a drug with an optimal efficacy/safety profile, providing the necessary analgesic effect in tension-type headache. TRPV1 brain receptors are considered the main action point of the mediator. Aim. The purpose of this study is a comparative analysis of the pharmacodynamic and pharmacokinetic parameters of ibuprofen and paracetamol as a part of fixed dose combination and as monotherapy in tension type headaches. Materials and methods. Comparative dissolution kinetics test; Comparative analysis of pharmacokinetic parameters using the PubMed/MEDLINE database. Results. The median Tmax of ibuprofen as a part of a fixed-dose combination and as a monotherapy is 75 minutes. The median Tmax of paracetamol is 30 min when taken in a fixed dose combination and 40 min as a monotherapy. In patients who received the fixed dose combination, the concentration of ibuprofen in the blood plasma after 10 minutes 6.64 g/ml-1; after 20 minutes 16.81 g/ml-1, while when taken in the same dose in as a monotherapy, respectively, 0.58 and 9.00 g/ml-1. The mean plasma concentrations of paracetamol after 10 and 20 minutes in patients receiving the fixed combination were 5.43 and 14.54 g/ml-1, respectively, compared with 0.33 and 9.19 g/ml-1 for paracetamol as monotherapy. dissolution kinetics test of the Paracytolgin: after 5 minutes, 20% of paracetamol passed into the solution in a system with a pH of 1.2; in a system with a pH of 4.5 36.4%; in a system with a pH of 6.8 33.5%; after 10 minutes, respectively 68.5, 98.0 and 89.6%. After 15 minutes, almost complete dissolution was noted in all systems: 98.5, 98.8 and 100.5%, respectively. Discussion. The combination of ibuprofen and paracetamol makes it possible to enhance the analgesic effect as a result of additive action by the help of central mechanisms. The fixed dose combination of ibuprofen and paracetamol significantly increases the rate of absorption of paracetamol, which has potential therapeutic benefits in terms of a faster analgesias onset. Conclusion. The fixed dose combination of ibuprofen and paracetamol provides faster and long-term anaesthesia with a comparatively lower dosage of each analgesic.Evgeniya V. ShikhEvgeniy D. KhaytovichAleksandr V. Perkov"Consilium Medicum" Publishing housearticlebuprofenparacetamolfixed dose combinationtension-type headacheMedicineRRUТерапевтический архив, Vol 93, Iss 8, Pp 862-868 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	buprofen paracetamol fixed dose combination tension-type headache Medicine R
spellingShingle	buprofen paracetamol fixed dose combination tension-type headache Medicine R Evgeniya V. Shikh Evgeniy D. Khaytovich Aleksandr V. Perkov Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
description	The article goes to describe clinical and pharmacological approaches to choosing a drug with an optimal efficacy/safety profile, providing the necessary analgesic effect in tension-type headache. TRPV1 brain receptors are considered the main action point of the mediator. Aim. The purpose of this study is a comparative analysis of the pharmacodynamic and pharmacokinetic parameters of ibuprofen and paracetamol as a part of fixed dose combination and as monotherapy in tension type headaches. Materials and methods. Comparative dissolution kinetics test; Comparative analysis of pharmacokinetic parameters using the PubMed/MEDLINE database. Results. The median Tmax of ibuprofen as a part of a fixed-dose combination and as a monotherapy is 75 minutes. The median Tmax of paracetamol is 30 min when taken in a fixed dose combination and 40 min as a monotherapy. In patients who received the fixed dose combination, the concentration of ibuprofen in the blood plasma after 10 minutes 6.64 g/ml-1; after 20 minutes 16.81 g/ml-1, while when taken in the same dose in as a monotherapy, respectively, 0.58 and 9.00 g/ml-1. The mean plasma concentrations of paracetamol after 10 and 20 minutes in patients receiving the fixed combination were 5.43 and 14.54 g/ml-1, respectively, compared with 0.33 and 9.19 g/ml-1 for paracetamol as monotherapy. dissolution kinetics test of the Paracytolgin: after 5 minutes, 20% of paracetamol passed into the solution in a system with a pH of 1.2; in a system with a pH of 4.5 36.4%; in a system with a pH of 6.8 33.5%; after 10 minutes, respectively 68.5, 98.0 and 89.6%. After 15 minutes, almost complete dissolution was noted in all systems: 98.5, 98.8 and 100.5%, respectively. Discussion. The combination of ibuprofen and paracetamol makes it possible to enhance the analgesic effect as a result of additive action by the help of central mechanisms. The fixed dose combination of ibuprofen and paracetamol significantly increases the rate of absorption of paracetamol, which has potential therapeutic benefits in terms of a faster analgesias onset. Conclusion. The fixed dose combination of ibuprofen and paracetamol provides faster and long-term anaesthesia with a comparatively lower dosage of each analgesic.
format	article
author	Evgeniya V. Shikh Evgeniy D. Khaytovich Aleksandr V. Perkov
author_facet	Evgeniya V. Shikh Evgeniy D. Khaytovich Aleksandr V. Perkov
author_sort	Evgeniya V. Shikh
title	Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
title_short	Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
title_full	Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
title_fullStr	Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
title_full_unstemmed	Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
title_sort	clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/584172845407419585c77fe5cd0ac8d6
work_keys_str_mv	AT evgeniyavshikh clinicalandpharmacologicalapproachestothechoiceofadrugforatensiontypeheadacherelief AT evgeniydkhaytovich clinicalandpharmacologicalapproachestothechoiceofadrugforatensiontypeheadacherelief AT aleksandrvperkov clinicalandpharmacologicalapproachestothechoiceofadrugforatensiontypeheadacherelief
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Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief

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