Macrophages employ quorum licensing to regulate collective activation

Macrophage activation is tightly regulated to maintain immune homeostasis, yet activation is also heterogeneous. Here, the authors show that macrophages coordinate activation by partitioning into two phenotypes that can nonlinearly amplify collective inflammatory cytokine production as a function of...

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Autores principales:	Joseph J. Muldoon, Yishan Chuang, Neda Bagheri, Joshua N. Leonard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5843764271434eebb99ebbcda964b4ae
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spelling	oai:doaj.org-article:5843764271434eebb99ebbcda964b4ae2021-12-02T17:33:14ZMacrophages employ quorum licensing to regulate collective activation10.1038/s41467-020-14547-y2041-1723https://doaj.org/article/5843764271434eebb99ebbcda964b4ae2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14547-yhttps://doaj.org/toc/2041-1723Macrophage activation is tightly regulated to maintain immune homeostasis, yet activation is also heterogeneous. Here, the authors show that macrophages coordinate activation by partitioning into two phenotypes that can nonlinearly amplify collective inflammatory cytokine production as a function of cell density.Joseph J. MuldoonYishan ChuangNeda BagheriJoshua N. LeonardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph J. Muldoon Yishan Chuang Neda Bagheri Joshua N. Leonard Macrophages employ quorum licensing to regulate collective activation
description	Macrophage activation is tightly regulated to maintain immune homeostasis, yet activation is also heterogeneous. Here, the authors show that macrophages coordinate activation by partitioning into two phenotypes that can nonlinearly amplify collective inflammatory cytokine production as a function of cell density.
format	article
author	Joseph J. Muldoon Yishan Chuang Neda Bagheri Joshua N. Leonard
author_facet	Joseph J. Muldoon Yishan Chuang Neda Bagheri Joshua N. Leonard
author_sort	Joseph J. Muldoon
title	Macrophages employ quorum licensing to regulate collective activation
title_short	Macrophages employ quorum licensing to regulate collective activation
title_full	Macrophages employ quorum licensing to regulate collective activation
title_fullStr	Macrophages employ quorum licensing to regulate collective activation
title_full_unstemmed	Macrophages employ quorum licensing to regulate collective activation
title_sort	macrophages employ quorum licensing to regulate collective activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5843764271434eebb99ebbcda964b4ae
work_keys_str_mv	AT josephjmuldoon macrophagesemployquorumlicensingtoregulatecollectiveactivation AT yishanchuang macrophagesemployquorumlicensingtoregulatecollectiveactivation AT nedabagheri macrophagesemployquorumlicensingtoregulatecollectiveactivation AT joshuanleonard macrophagesemployquorumlicensingtoregulatecollectiveactivation
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Macrophages employ quorum licensing to regulate collective activation

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