Macrophages employ quorum licensing to regulate collective activation

Macrophage activation is tightly regulated to maintain immune homeostasis, yet activation is also heterogeneous. Here, the authors show that macrophages coordinate activation by partitioning into two phenotypes that can nonlinearly amplify collective inflammatory cytokine production as a function of...

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Autores principales: Joseph J. Muldoon, Yishan Chuang, Neda Bagheri, Joshua N. Leonard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5843764271434eebb99ebbcda964b4ae
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