Validating a Numerical Simulation of Human Heart Motion Using Clinical Data

Numerical simulations are increasingly often involved in developing new and improving existing medical therapies. While the models involved in those simulations are designed to resemble a specific phenomenon realistically, the results of the interplay of those models are often not sufficiently valid...

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Autores principales:	Müller Armin, Kovacheva Ekaterina, Fritz Marc Alexander, Dössel Olaf, Loewe Axel
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	simulation validation numerical simulation clinical data motion deformation human heart Medicine R
Acceso en línea:	https://doaj.org/article/58448585e51f4328bce51052ef0efadb
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id	oai:doaj.org-article:58448585e51f4328bce51052ef0efadb
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spelling	oai:doaj.org-article:58448585e51f4328bce51052ef0efadb2021-12-05T14:10:43ZValidating a Numerical Simulation of Human Heart Motion Using Clinical Data2364-550410.1515/cdbme-2020-3140https://doaj.org/article/58448585e51f4328bce51052ef0efadb2020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3140https://doaj.org/toc/2364-5504Numerical simulations are increasingly often involved in developing new and improving existing medical therapies. While the models involved in those simulations are designed to resemble a specific phenomenon realistically, the results of the interplay of those models are often not sufficiently validated. We created a plugin for a cardiac simulation framework to validate the simulation results using clinical MRI data. The MRI data were used to create a static wholeheart mesh as well as slices from the left ventricular short axis, providing the motion over time. The static heart was a starting point for a simulation of the heart’s motion. From the simulation result, we created slices and compared them to the clinical MRI slices using two different metrics: the area of the slices and the point distances. The comparison showed global similarities in the deformation of simulated and clinical data, but also indicated points for potential improvements. Performing this comparison with more clinical data could lead to personalized modeling of elastomechanics of the heart.Müller ArminKovacheva EkaterinaFritz Marc AlexanderDössel OlafLoewe AxelDe Gruyterarticlesimulation validationnumerical simulationclinical datamotion deformationhuman heartMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 547-550 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	simulation validation numerical simulation clinical data motion deformation human heart Medicine R
spellingShingle	simulation validation numerical simulation clinical data motion deformation human heart Medicine R Müller Armin Kovacheva Ekaterina Fritz Marc Alexander Dössel Olaf Loewe Axel Validating a Numerical Simulation of Human Heart Motion Using Clinical Data
description	Numerical simulations are increasingly often involved in developing new and improving existing medical therapies. While the models involved in those simulations are designed to resemble a specific phenomenon realistically, the results of the interplay of those models are often not sufficiently validated. We created a plugin for a cardiac simulation framework to validate the simulation results using clinical MRI data. The MRI data were used to create a static wholeheart mesh as well as slices from the left ventricular short axis, providing the motion over time. The static heart was a starting point for a simulation of the heart’s motion. From the simulation result, we created slices and compared them to the clinical MRI slices using two different metrics: the area of the slices and the point distances. The comparison showed global similarities in the deformation of simulated and clinical data, but also indicated points for potential improvements. Performing this comparison with more clinical data could lead to personalized modeling of elastomechanics of the heart.
format	article
author	Müller Armin Kovacheva Ekaterina Fritz Marc Alexander Dössel Olaf Loewe Axel
author_facet	Müller Armin Kovacheva Ekaterina Fritz Marc Alexander Dössel Olaf Loewe Axel
author_sort	Müller Armin
title	Validating a Numerical Simulation of Human Heart Motion Using Clinical Data
title_short	Validating a Numerical Simulation of Human Heart Motion Using Clinical Data
title_full	Validating a Numerical Simulation of Human Heart Motion Using Clinical Data
title_fullStr	Validating a Numerical Simulation of Human Heart Motion Using Clinical Data
title_full_unstemmed	Validating a Numerical Simulation of Human Heart Motion Using Clinical Data
title_sort	validating a numerical simulation of human heart motion using clinical data
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/58448585e51f4328bce51052ef0efadb
work_keys_str_mv	AT mullerarmin validatinganumericalsimulationofhumanheartmotionusingclinicaldata AT kovachevaekaterina validatinganumericalsimulationofhumanheartmotionusingclinicaldata AT fritzmarcalexander validatinganumericalsimulationofhumanheartmotionusingclinicaldata AT dosselolaf validatinganumericalsimulationofhumanheartmotionusingclinicaldata AT loeweaxel validatinganumericalsimulationofhumanheartmotionusingclinicaldata
_version_	1718371786979016704

Validating a Numerical Simulation of Human Heart Motion Using Clinical Data

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