Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

Integrin-linked kinase (ILK) is an important mediator of integrin signaling. Here Park et al. show that mice with endothelial-specific deletion of Ilk develop vascular defects that resemble familial exudative vitreoretinopathy, and identify mutations in ILK in patients with exudative vitreoretinopat...

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Autores principales:	Hongryeol Park, Hiroyuki Yamamoto, Lucas Mohn, Lea Ambühl, Kenichi Kanai, Inga Schmidt, Kee-Pyo Kim, Alessia Fraccaroli, Silke Feil, Harald J. Junge, Eloi Montanez, Wolfgang Berger, Ralf H. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/584556069c6146ea98a94e8f212f9037
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spelling	oai:doaj.org-article:584556069c6146ea98a94e8f212f90372021-12-02T15:35:29ZIntegrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy10.1038/s41467-019-13220-32041-1723https://doaj.org/article/584556069c6146ea98a94e8f212f90372019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13220-3https://doaj.org/toc/2041-1723Integrin-linked kinase (ILK) is an important mediator of integrin signaling. Here Park et al. show that mice with endothelial-specific deletion of Ilk develop vascular defects that resemble familial exudative vitreoretinopathy, and identify mutations in ILK in patients with exudative vitreoretinopathy suggesting a potential role in human pathogenesis.Hongryeol ParkHiroyuki YamamotoLucas MohnLea AmbühlKenichi KanaiInga SchmidtKee-Pyo KimAlessia FraccaroliSilke FeilHarald J. JungeEloi MontanezWolfgang BergerRalf H. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongryeol Park Hiroyuki Yamamoto Lucas Mohn Lea Ambühl Kenichi Kanai Inga Schmidt Kee-Pyo Kim Alessia Fraccaroli Silke Feil Harald J. Junge Eloi Montanez Wolfgang Berger Ralf H. Adams Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
description	Integrin-linked kinase (ILK) is an important mediator of integrin signaling. Here Park et al. show that mice with endothelial-specific deletion of Ilk develop vascular defects that resemble familial exudative vitreoretinopathy, and identify mutations in ILK in patients with exudative vitreoretinopathy suggesting a potential role in human pathogenesis.
format	article
author	Hongryeol Park Hiroyuki Yamamoto Lucas Mohn Lea Ambühl Kenichi Kanai Inga Schmidt Kee-Pyo Kim Alessia Fraccaroli Silke Feil Harald J. Junge Eloi Montanez Wolfgang Berger Ralf H. Adams
author_facet	Hongryeol Park Hiroyuki Yamamoto Lucas Mohn Lea Ambühl Kenichi Kanai Inga Schmidt Kee-Pyo Kim Alessia Fraccaroli Silke Feil Harald J. Junge Eloi Montanez Wolfgang Berger Ralf H. Adams
author_sort	Hongryeol Park
title	Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
title_short	Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
title_full	Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
title_fullStr	Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
title_full_unstemmed	Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
title_sort	integrin-linked kinase controls retinal angiogenesis and is linked to wnt signaling and exudative vitreoretinopathy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/584556069c6146ea98a94e8f212f9037
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Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

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