Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability

Sergio L Schmidt,1,2 Michele Santos da Silva,2 Juliana J Schmidt,2 Ana Lucia Novais Carvalho,3 Claudia Cristina Ferreira Vasconcelos,2 Renata Alves Paes,2 Yolanda EM Boechat,4 Rafael Neder,2 Regina P Alvarenga2 1Department of Neurophysiology, State University of Rio de Janeiro, RJ, Brazil; 2Neurolo...

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Autores principales:	Schmidt SL, Santos da Silva M, Schmidt JJ, Carvalho ALN, Vasconcelos CCF, Paes RA, Boechat YEM, Neder R, Alvarenga RP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Processing Speed Cognitive Impairments Neuropsychology Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5848f077a76e40a39d30825f0acdc278
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spelling	oai:doaj.org-article:5848f077a76e40a39d30825f0acdc2782021-12-02T00:14:15ZNeuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability1178-2021https://doaj.org/article/5848f077a76e40a39d30825f0acdc2782018-06-01T00:00:00Zhttps://www.dovepress.com/neuropsychiatric-assessments-in-patients-with-multiple-sclerosis-in-ea-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Sergio L Schmidt,1,2 Michele Santos da Silva,2 Juliana J Schmidt,2 Ana Lucia Novais Carvalho,3 Claudia Cristina Ferreira Vasconcelos,2 Renata Alves Paes,2 Yolanda EM Boechat,4 Rafael Neder,2 Regina P Alvarenga2 1Department of Neurophysiology, State University of Rio de Janeiro, RJ, Brazil; 2Neurology Department, Federal University of the State of Rio de Janeiro, RJ, Brazil; 3Department of Psychology, Fluminense Federal University, Niteroi, Brazil; 4Department of Internal Medicine, Fluminense Federal University, Niteroi, Brazil Background: In the early phases of multiple sclerosis (MS), patients exhibit slight neuropsychiatric deficits that can only be detected using reliable tools. Aim: The present investigation aimed to examine neuropsychological performance in 35 patients with incipient MS. Patients and methods: For the MS group, the inclusion criteria included time of disease <3 years and low disability. The neuropsychological battery consisted of Rey Auditory Learning Test, Controlled Oral Word Association Test, Hooper Visual Organization Test, and Symbol Digit Modalities Test (SDMT). Results: After correction for the educational level, no significant effect of MS on performance was found for all the tests except for the number of errors of the SDMT (NE-SDMT). Higher levels of education were associated with better performances in all tests, except for the NE-SDMT. MS patients made more errors than the controls. Conclusion: The effect on the NE-SDMT may reflect difficulties in the ability to inhibit inadequate responses. Patients may exhibit impulsive control disorders in incipient MS, independent of their educational level. Keywords: processing speed, cognitive impairments, neuropsychologySchmidt SLSantos da Silva MSchmidt JJCarvalho ALNVasconcelos CCFPaes RABoechat YEMNeder RAlvarenga RPDove Medical PressarticleProcessing SpeedCognitive ImpairmentsNeuropsychologyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1665-1670 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Processing Speed Cognitive Impairments Neuropsychology Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Processing Speed Cognitive Impairments Neuropsychology Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Schmidt SL Santos da Silva M Schmidt JJ Carvalho ALN Vasconcelos CCF Paes RA Boechat YEM Neder R Alvarenga RP Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
description	Sergio L Schmidt,1,2 Michele Santos da Silva,2 Juliana J Schmidt,2 Ana Lucia Novais Carvalho,3 Claudia Cristina Ferreira Vasconcelos,2 Renata Alves Paes,2 Yolanda EM Boechat,4 Rafael Neder,2 Regina P Alvarenga2 1Department of Neurophysiology, State University of Rio de Janeiro, RJ, Brazil; 2Neurology Department, Federal University of the State of Rio de Janeiro, RJ, Brazil; 3Department of Psychology, Fluminense Federal University, Niteroi, Brazil; 4Department of Internal Medicine, Fluminense Federal University, Niteroi, Brazil Background: In the early phases of multiple sclerosis (MS), patients exhibit slight neuropsychiatric deficits that can only be detected using reliable tools. Aim: The present investigation aimed to examine neuropsychological performance in 35 patients with incipient MS. Patients and methods: For the MS group, the inclusion criteria included time of disease <3 years and low disability. The neuropsychological battery consisted of Rey Auditory Learning Test, Controlled Oral Word Association Test, Hooper Visual Organization Test, and Symbol Digit Modalities Test (SDMT). Results: After correction for the educational level, no significant effect of MS on performance was found for all the tests except for the number of errors of the SDMT (NE-SDMT). Higher levels of education were associated with better performances in all tests, except for the NE-SDMT. MS patients made more errors than the controls. Conclusion: The effect on the NE-SDMT may reflect difficulties in the ability to inhibit inadequate responses. Patients may exhibit impulsive control disorders in incipient MS, independent of their educational level. Keywords: processing speed, cognitive impairments, neuropsychology
format	article
author	Schmidt SL Santos da Silva M Schmidt JJ Carvalho ALN Vasconcelos CCF Paes RA Boechat YEM Neder R Alvarenga RP
author_facet	Schmidt SL Santos da Silva M Schmidt JJ Carvalho ALN Vasconcelos CCF Paes RA Boechat YEM Neder R Alvarenga RP
author_sort	Schmidt SL
title	Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
title_short	Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
title_full	Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
title_fullStr	Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
title_full_unstemmed	Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
title_sort	neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5848f077a76e40a39d30825f0acdc278
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Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability

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