Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study

Henok Getachew, Akshaya Srikanth Bhagavathula, Tamrat Befekadu Abebe, Sewunet Admasu Belachew Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Background: Inappropriate use of antiplatelets and anticoagulants among...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Getachew H, Bhagavathula AS, Abebe TB, Belachew SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Prevalence Inappropriate prescribing Antithrombotic STOPP/START criteria Elderly Ethiopia Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/584b705b3d2d4bb599879bf0c539b159
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:584b705b3d2d4bb599879bf0c539b159
record_format	dspace
spelling	oai:doaj.org-article:584b705b3d2d4bb599879bf0c539b1592021-12-02T03:14:27ZInappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study1178-1998https://doaj.org/article/584b705b3d2d4bb599879bf0c539b1592016-06-01T00:00:00Zhttps://www.dovepress.com/inappropriate-prescribing-of-antithrombotic-therapy-in-ethiopian-elder-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Henok Getachew, Akshaya Srikanth Bhagavathula, Tamrat Befekadu Abebe, Sewunet Admasu Belachew Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Background: Inappropriate use of antiplatelets and anticoagulants among elderly patients increases the risk of adverse outcomes. The aim of this study was to assess the prevalence of inappropriate prescribing of antithrombotic therapy in hospitalized elderly patients. Methods: A retrospective cross-sectional, single-center study was conducted at the Gondar University Hospital. A total of 156 hospitalized elderly patients fulfilling the inclusion/exclusion criteria were included in the study. The Screening Tool for Older Person’s Prescription/Screening Tool to Alert doctors to Right Treatment criteria version 2 were applied to patients’ data to identify the total number of inappropriate prescribing (IPs) including potentially inappropriate medications and potential prescribing omissions. Results: A total of 70 IPs were identified in 156 patients who met the inclusion criteria. Of these, 36 (51.4%) were identified as potentially inappropriate medications by the Screening Tool for Older Person’s Prescription criteria. The prevalence of IP per patient indicated that 58 of the 156 (37.2%) patients were exposed to at least one IP. Of these, 32 (55.2%) had at least one potentially inappropriate medication and 33 (56.9%) had at least one potential prescribing omission. Patients hospitalized due to venous thromboembolism (adjusted odds ratio [AOR] =29.87, 95% confidence interval [CI], 1.26–708.6), stroke (AOR =7.74, 95% CI, 1.27–47.29), or acute coronary syndrome (AOR =13.48, 95% CI, 1.4–129.1) were less likely to be exposed to an IP. An increase in Charlson comorbidity index score was associated with increased IP exposure (AOR =0.60, 95% CI, 0.39–0.945). IPs were about six times more likely to absent in patients prescribed with antiplatelet only therapy (AOR =6.23, 95% CI, 1.90–20.37) than those receiving any other groups of antithrombotics. Conclusion: IPs are less common in elderly patients primarily admitted due to venous thromboembolism, stroke, and acute coronary syndrome, and those elderly patients prescribed with only antiplatelet. Patients with higher Charlson comorbidity index were, however, associated with increased IPs exposure. Our study may guide further research to reduce high-risk prescription of antithrombotics in the elderly. Keywords: prevalence, inappropriate prescribing, antithrombotic, STOPP/START criteria, elderly, EthiopiaGetachew HBhagavathula ASAbebe TBBelachew SADove Medical PressarticlePrevalenceInappropriate prescribingAntithromboticSTOPP/START criteriaElderlyEthiopiaGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 819-827 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prevalence Inappropriate prescribing Antithrombotic STOPP/START criteria Elderly Ethiopia Geriatrics RC952-954.6
spellingShingle	Prevalence Inappropriate prescribing Antithrombotic STOPP/START criteria Elderly Ethiopia Geriatrics RC952-954.6 Getachew H Bhagavathula AS Abebe TB Belachew SA Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study
description	Henok Getachew, Akshaya Srikanth Bhagavathula, Tamrat Befekadu Abebe, Sewunet Admasu Belachew Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Background: Inappropriate use of antiplatelets and anticoagulants among elderly patients increases the risk of adverse outcomes. The aim of this study was to assess the prevalence of inappropriate prescribing of antithrombotic therapy in hospitalized elderly patients. Methods: A retrospective cross-sectional, single-center study was conducted at the Gondar University Hospital. A total of 156 hospitalized elderly patients fulfilling the inclusion/exclusion criteria were included in the study. The Screening Tool for Older Person’s Prescription/Screening Tool to Alert doctors to Right Treatment criteria version 2 were applied to patients’ data to identify the total number of inappropriate prescribing (IPs) including potentially inappropriate medications and potential prescribing omissions. Results: A total of 70 IPs were identified in 156 patients who met the inclusion criteria. Of these, 36 (51.4%) were identified as potentially inappropriate medications by the Screening Tool for Older Person’s Prescription criteria. The prevalence of IP per patient indicated that 58 of the 156 (37.2%) patients were exposed to at least one IP. Of these, 32 (55.2%) had at least one potentially inappropriate medication and 33 (56.9%) had at least one potential prescribing omission. Patients hospitalized due to venous thromboembolism (adjusted odds ratio [AOR] =29.87, 95% confidence interval [CI], 1.26–708.6), stroke (AOR =7.74, 95% CI, 1.27–47.29), or acute coronary syndrome (AOR =13.48, 95% CI, 1.4–129.1) were less likely to be exposed to an IP. An increase in Charlson comorbidity index score was associated with increased IP exposure (AOR =0.60, 95% CI, 0.39–0.945). IPs were about six times more likely to absent in patients prescribed with antiplatelet only therapy (AOR =6.23, 95% CI, 1.90–20.37) than those receiving any other groups of antithrombotics. Conclusion: IPs are less common in elderly patients primarily admitted due to venous thromboembolism, stroke, and acute coronary syndrome, and those elderly patients prescribed with only antiplatelet. Patients with higher Charlson comorbidity index were, however, associated with increased IPs exposure. Our study may guide further research to reduce high-risk prescription of antithrombotics in the elderly. Keywords: prevalence, inappropriate prescribing, antithrombotic, STOPP/START criteria, elderly, Ethiopia
format	article
author	Getachew H Bhagavathula AS Abebe TB Belachew SA
author_facet	Getachew H Bhagavathula AS Abebe TB Belachew SA
author_sort	Getachew H
title	Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study
title_short	Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study
title_full	Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study
title_fullStr	Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study
title_full_unstemmed	Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study
title_sort	inappropriate prescribing of antithrombotic therapy in ethiopian elderly population using updated 2015 stopp/start criteria: a cross-sectional study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/584b705b3d2d4bb599879bf0c539b159
work_keys_str_mv	AT getachewh inappropriateprescribingofantithrombotictherapyinethiopianelderlypopulationusingupdated2015stoppstartcriteriaacrosssectionalstudy AT bhagavathulaas inappropriateprescribingofantithrombotictherapyinethiopianelderlypopulationusingupdated2015stoppstartcriteriaacrosssectionalstudy AT abebetb inappropriateprescribingofantithrombotictherapyinethiopianelderlypopulationusingupdated2015stoppstartcriteriaacrosssectionalstudy AT belachewsa inappropriateprescribingofantithrombotictherapyinethiopianelderlypopulationusingupdated2015stoppstartcriteriaacrosssectionalstudy
_version_	1718401854586486784

Inappropriate prescribing of antithrombotic therapy in Ethiopian elderly population using updated 2015 STOPP/START criteria: a cross-sectional study

Ejemplares similares