Exosome mimetics: a novel class of drug delivery systems

Sander AA Kooijmans, Pieter Vader, Susan M van Dommelen, Wouter W van Solinge, Raymond M SchiffelersDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsAbstract: The identification of extracellular phospholipid vesicles as conveyors of cellula...

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Autores principales:	Kooijmans SAA, Vader P, van Dommelen SM, van Solinge WW, Schiffelers RM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/584cda0c72fa45f6ab0b71f495c42d42
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spelling	oai:doaj.org-article:584cda0c72fa45f6ab0b71f495c42d422021-12-02T03:03:55ZExosome mimetics: a novel class of drug delivery systems1176-91141178-2013https://doaj.org/article/584cda0c72fa45f6ab0b71f495c42d422012-03-01T00:00:00Zhttp://www.dovepress.com/exosome-mimetics-a-novel-class-of-drug-delivery-systems-a9513https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sander AA Kooijmans, Pieter Vader, Susan M van Dommelen, Wouter W van Solinge, Raymond M SchiffelersDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsAbstract: The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short interfering RNA and recombinant proteins, are prone to degradation, have limited ability to cross biological membranes, and may elicit immune responses. Therefore, delivery systems for such drugs are under intensive investigation. Exploiting extracellular vesicles as carriers for biological therapeutics is a promising strategy to overcome these issues and to achieve efficient delivery to the cytosol of target cells. Exosomes are a well studied class of extracellular vesicles known to carry proteins and nucleic acids, making them especially suitable for such strategies. However, the considerable complexity and the related high chance of off-target effects of these carriers are major barriers for translation to the clinic. Given that it is well possible that not all components of exosomes are required for their proper functioning, an alternative strategy would be to mimic these vesicles synthetically. By assembly of liposomes harboring only crucial components of natural exosomes, functional exosome mimetics may be created. The low complexity and use of well characterized components strongly increase the pharmaceutical acceptability of such systems. However, exosomal components that would be required for the assembly of functional exosome mimetics remain to be identified. This review provides insights into the composition and functional properties of exosomes, and focuses on components which could be used to enhance the drug delivery properties of exosome mimetics.Keywords: exosomes, extracellular vesicles, liposomes, drug delivery systemsKooijmans SAAVader Pvan Dommelen SMvan Solinge WWSchiffelers RMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1525-1541 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kooijmans SAA Vader P van Dommelen SM van Solinge WW Schiffelers RM Exosome mimetics: a novel class of drug delivery systems
description	Sander AA Kooijmans, Pieter Vader, Susan M van Dommelen, Wouter W van Solinge, Raymond M SchiffelersDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsAbstract: The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short interfering RNA and recombinant proteins, are prone to degradation, have limited ability to cross biological membranes, and may elicit immune responses. Therefore, delivery systems for such drugs are under intensive investigation. Exploiting extracellular vesicles as carriers for biological therapeutics is a promising strategy to overcome these issues and to achieve efficient delivery to the cytosol of target cells. Exosomes are a well studied class of extracellular vesicles known to carry proteins and nucleic acids, making them especially suitable for such strategies. However, the considerable complexity and the related high chance of off-target effects of these carriers are major barriers for translation to the clinic. Given that it is well possible that not all components of exosomes are required for their proper functioning, an alternative strategy would be to mimic these vesicles synthetically. By assembly of liposomes harboring only crucial components of natural exosomes, functional exosome mimetics may be created. The low complexity and use of well characterized components strongly increase the pharmaceutical acceptability of such systems. However, exosomal components that would be required for the assembly of functional exosome mimetics remain to be identified. This review provides insights into the composition and functional properties of exosomes, and focuses on components which could be used to enhance the drug delivery properties of exosome mimetics.Keywords: exosomes, extracellular vesicles, liposomes, drug delivery systems
format	article
author	Kooijmans SAA Vader P van Dommelen SM van Solinge WW Schiffelers RM
author_facet	Kooijmans SAA Vader P van Dommelen SM van Solinge WW Schiffelers RM
author_sort	Kooijmans SAA
title	Exosome mimetics: a novel class of drug delivery systems
title_short	Exosome mimetics: a novel class of drug delivery systems
title_full	Exosome mimetics: a novel class of drug delivery systems
title_fullStr	Exosome mimetics: a novel class of drug delivery systems
title_full_unstemmed	Exosome mimetics: a novel class of drug delivery systems
title_sort	exosome mimetics: a novel class of drug delivery systems
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/584cda0c72fa45f6ab0b71f495c42d42
work_keys_str_mv	AT kooijmanssaa exosomemimeticsanovelclassofdrugdeliverysystems AT vaderp exosomemimeticsanovelclassofdrugdeliverysystems AT vandommelensm exosomemimeticsanovelclassofdrugdeliverysystems AT vansolingeww exosomemimeticsanovelclassofdrugdeliverysystems AT schiffelersrm exosomemimeticsanovelclassofdrugdeliverysystems
_version_	1718401985644855296

Exosome mimetics: a novel class of drug delivery systems

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