The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia
Abstract Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood. Previous studies of etiology and pathogenesis of AIHA mainly focus on autor...
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Nature Portfolio
2019
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oai:doaj.org-article:584d8bd8b4fe46d8b1b172d6ba617fbc2021-12-02T13:34:55ZThe Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia10.1038/s41598-019-56365-32045-2322https://doaj.org/article/584d8bd8b4fe46d8b1b172d6ba617fbc2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56365-3https://doaj.org/toc/2045-2322Abstract Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood. Previous studies of etiology and pathogenesis of AIHA mainly focus on autoreactive B cells that have escaped tolerance mechanisms. Few studies have reported the function of TFH and TFR cells in the process of AIHA. The present study aimed to explore the potential mechanism of TFH and TFR cells in the pathogenesis of AIHA. With the model of murine AIHA, increased ratios of TFH:TFR, elevated serum IL-21 and IL-6 levels, and upregulated Bcl-6 and c-Maf expression were reported. Also, adoptive transfer of purified CD4+CXCR5+CD25- T cells from immunized mice promoted the induction of autoantibody in the AIHA mouse model. Altogether, our data demonstrate the important role of TFH cells for control and induction of AIHA. In the light of the key contributions of TFH cells to the immune response in AIHA, strategies aimed at inhibiting the TFH development or function should be emphasized.Yuhan GaoHaiqiang JinDing NanWeiwei YuJianhua ZhangYing YangRuiqin HouRanran QinHongjun HaoYongan SunWenqin TianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
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Medicine R Science Q Yuhan Gao Haiqiang Jin Ding Nan Weiwei Yu Jianhua Zhang Ying Yang Ruiqin Hou Ranran Qin Hongjun Hao Yongan Sun Wenqin Tian The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia |
| description |
Abstract Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood. Previous studies of etiology and pathogenesis of AIHA mainly focus on autoreactive B cells that have escaped tolerance mechanisms. Few studies have reported the function of TFH and TFR cells in the process of AIHA. The present study aimed to explore the potential mechanism of TFH and TFR cells in the pathogenesis of AIHA. With the model of murine AIHA, increased ratios of TFH:TFR, elevated serum IL-21 and IL-6 levels, and upregulated Bcl-6 and c-Maf expression were reported. Also, adoptive transfer of purified CD4+CXCR5+CD25- T cells from immunized mice promoted the induction of autoantibody in the AIHA mouse model. Altogether, our data demonstrate the important role of TFH cells for control and induction of AIHA. In the light of the key contributions of TFH cells to the immune response in AIHA, strategies aimed at inhibiting the TFH development or function should be emphasized. |
| format |
article |
| author |
Yuhan Gao Haiqiang Jin Ding Nan Weiwei Yu Jianhua Zhang Ying Yang Ruiqin Hou Ranran Qin Hongjun Hao Yongan Sun Wenqin Tian |
| author_facet |
Yuhan Gao Haiqiang Jin Ding Nan Weiwei Yu Jianhua Zhang Ying Yang Ruiqin Hou Ranran Qin Hongjun Hao Yongan Sun Wenqin Tian |
| author_sort |
Yuhan Gao |
| title |
The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia |
| title_short |
The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia |
| title_full |
The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia |
| title_fullStr |
The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia |
| title_full_unstemmed |
The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia |
| title_sort |
role of t follicular helper cells and t follicular regulatory cells in the pathogenesis of autoimmune hemolytic anemia |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/584d8bd8b4fe46d8b1b172d6ba617fbc |
| work_keys_str_mv |
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