Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.

Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2). We m...

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Autores principales:	B M Hooks, S Andrew Hires, Ying-Xin Zhang, Daniel Huber, Leopoldo Petreanu, Karel Svoboda, Gordon M G Shepherd
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/58502a9528854e3e99cd448fc311da7d
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spelling	oai:doaj.org-article:58502a9528854e3e99cd448fc311da7d2021-11-18T05:36:23ZLaminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.1544-91731545-788510.1371/journal.pbio.1000572https://doaj.org/article/58502a9528854e3e99cd448fc311da7d2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21245906/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2). We mapped local excitatory pathways in each area across all cortical layers using glutamate uncaging and laser scanning photostimulation. We analyzed these maps to derive laminar connectivity matrices describing the average strengths of pathways between individual neurons in different layers and between entire cortical layers. In vM1, the strongest projection was L2/3→L5. In vS1, strong projections were L2/3→L5 and L4→L3. L6 input and output were weak in both areas. In S2, L2/3→L5 exceeded the strength of the ascending L4→L3 projection, and local input to L6 was prominent. The most conserved pathways were L2/3→L5, and the most variable were L4→L2/3 and pathways involving L6. Local excitatory circuits in different cortical areas are organized around a prominent descending pathway from L2/3→L5, suggesting that sensory cortices are elaborations on a basic motor cortex-like plan.B M HooksS Andrew HiresYing-Xin ZhangDaniel HuberLeopoldo PetreanuKarel SvobodaGordon M G ShepherdPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 9, Iss 1, p e1000572 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 B M Hooks S Andrew Hires Ying-Xin Zhang Daniel Huber Leopoldo Petreanu Karel Svoboda Gordon M G Shepherd Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
description	Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2). We mapped local excitatory pathways in each area across all cortical layers using glutamate uncaging and laser scanning photostimulation. We analyzed these maps to derive laminar connectivity matrices describing the average strengths of pathways between individual neurons in different layers and between entire cortical layers. In vM1, the strongest projection was L2/3→L5. In vS1, strong projections were L2/3→L5 and L4→L3. L6 input and output were weak in both areas. In S2, L2/3→L5 exceeded the strength of the ascending L4→L3 projection, and local input to L6 was prominent. The most conserved pathways were L2/3→L5, and the most variable were L4→L2/3 and pathways involving L6. Local excitatory circuits in different cortical areas are organized around a prominent descending pathway from L2/3→L5, suggesting that sensory cortices are elaborations on a basic motor cortex-like plan.
format	article
author	B M Hooks S Andrew Hires Ying-Xin Zhang Daniel Huber Leopoldo Petreanu Karel Svoboda Gordon M G Shepherd
author_facet	B M Hooks S Andrew Hires Ying-Xin Zhang Daniel Huber Leopoldo Petreanu Karel Svoboda Gordon M G Shepherd
author_sort	B M Hooks
title	Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
title_short	Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
title_full	Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
title_fullStr	Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
title_full_unstemmed	Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
title_sort	laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/58502a9528854e3e99cd448fc311da7d
work_keys_str_mv	AT bmhooks laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas AT sandrewhires laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas AT yingxinzhang laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas AT danielhuber laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas AT leopoldopetreanu laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas AT karelsvoboda laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas AT gordonmgshepherd laminaranalysisofexcitatorylocalcircuitsinvibrissalmotorandsensorycorticalareas
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Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas.

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