Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study

The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between internet...

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Autores principales:	Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5851f9cbdf2e419fbdd3f2f18ecb3153
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spelling	oai:doaj.org-article:5851f9cbdf2e419fbdd3f2f18ecb31532021-11-25T05:54:27ZBrain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study1932-6203https://doaj.org/article/5851f9cbdf2e419fbdd3f2f18ecb31532021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592411/?tool=EBIhttps://doaj.org/toc/1932-6203The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between internet addiction tendency (IAT) score and regional gray and white matter volumes (rGMVs and rWMVs) and brain activity during a WM task in a large sample of healthy young adults (n = 1,154, mean age, 20.71 ± 1.78 years). We found a significant positive correlation between IAT score and gray matter volume (GMV) of right supramarginal gyrus (rSMG) and significant negative correlations with white matter volume (WMV) of right temporal lobe (sub-gyral and superior temporal gyrus), right sublobar area (extra-nuclear and lentiform nucleus), right cerebellar anterior lobe, cerebellar tonsil, right frontal lobe (inferior frontal gyrus and sub-gyral areas), and the pons. Also, IAT was significantly and positively correlated with brain activity in the default-mode network (DMN), medial frontal gyrus, medial part of the superior frontal gyrus, and anterior cingulate cortex during a 2-back working memory (WM) task. Moreover, whole-brain analyses of rGMV showed significant effects of interaction between sex and the IAT scores in the area spreading around the left anterior insula and left lentiform. This interaction was moderated by positive correlation in women. These results indicate that IAT is associated with (a) increased GMV in rSMG, which is involved in phonological processing, (b) decreased WMV in areas of frontal, sublobar, and temporal lobes, which are involved in response inhibition, and (c) reduced task-induced deactivation of the DMN, indicative of altered attentional allocation.Saeid SadeghiHikaru TakeuchiBita ShalaniYasuyuki TakiRui NouchiRyoichi YokoyamaYuka KotozakiSeishu NakagawaAtsushi SekiguchiKunio IizukaSugiko HanawaTsuyoshi ArakiCarlos Makoto MiyauchiKohei SakakiTakayuki NozawaShigeyuki IkedaSusumu YokotaDaniele MagistroYuko SassaRyuta KawashimaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saeid Sadeghi Hikaru Takeuchi Bita Shalani Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Kohei Sakaki Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Daniele Magistro Yuko Sassa Ryuta Kawashima Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study
description	The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between internet addiction tendency (IAT) score and regional gray and white matter volumes (rGMVs and rWMVs) and brain activity during a WM task in a large sample of healthy young adults (n = 1,154, mean age, 20.71 ± 1.78 years). We found a significant positive correlation between IAT score and gray matter volume (GMV) of right supramarginal gyrus (rSMG) and significant negative correlations with white matter volume (WMV) of right temporal lobe (sub-gyral and superior temporal gyrus), right sublobar area (extra-nuclear and lentiform nucleus), right cerebellar anterior lobe, cerebellar tonsil, right frontal lobe (inferior frontal gyrus and sub-gyral areas), and the pons. Also, IAT was significantly and positively correlated with brain activity in the default-mode network (DMN), medial frontal gyrus, medial part of the superior frontal gyrus, and anterior cingulate cortex during a 2-back working memory (WM) task. Moreover, whole-brain analyses of rGMV showed significant effects of interaction between sex and the IAT scores in the area spreading around the left anterior insula and left lentiform. This interaction was moderated by positive correlation in women. These results indicate that IAT is associated with (a) increased GMV in rSMG, which is involved in phonological processing, (b) decreased WMV in areas of frontal, sublobar, and temporal lobes, which are involved in response inhibition, and (c) reduced task-induced deactivation of the DMN, indicative of altered attentional allocation.
format	article
author	Saeid Sadeghi Hikaru Takeuchi Bita Shalani Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Kohei Sakaki Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Daniele Magistro Yuko Sassa Ryuta Kawashima
author_facet	Saeid Sadeghi Hikaru Takeuchi Bita Shalani Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Kohei Sakaki Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Daniele Magistro Yuko Sassa Ryuta Kawashima
author_sort	Saeid Sadeghi
title	Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study
title_short	Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study
title_full	Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study
title_fullStr	Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study
title_full_unstemmed	Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study
title_sort	brain structures and activity during a working memory task associated with internet addiction tendency in young adults: a large sample study
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5851f9cbdf2e419fbdd3f2f18ecb3153
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Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study

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