Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>

ABSTRACT The transmission of the bacterium Streptococcus pneumoniae (the pneumococcus) marks the first step toward disease development. To date, our ability to prevent pneumococcal transmission has been limited by our lack of understanding regarding the factors which influence the spread of this pat...

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Autores principales: Kirsty R. Short, Patrick C. Reading, Nancy Wang, Dimitri A. Diavatopoulos, Odilia L. Wijburg
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Publicado: American Society for Microbiology 2012
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spelling oai:doaj.org-article:5853be03136247adae08916e552db3242021-11-15T15:39:12ZIncreased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>10.1128/mBio.00255-122150-7511https://doaj.org/article/5853be03136247adae08916e552db3242012-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00255-12https://doaj.org/toc/2150-7511ABSTRACT The transmission of the bacterium Streptococcus pneumoniae (the pneumococcus) marks the first step toward disease development. To date, our ability to prevent pneumococcal transmission has been limited by our lack of understanding regarding the factors which influence the spread of this pathogen. We have previously developed an infant mouse model of pneumococcal transmission which was strictly dependent on influenza A virus (IAV) coinfection of both the experimentally colonized “index mice” and the naive cohoused “contact mice.” Here, we sought to use this model to further elucidate the factors which facilitate S. pneumoniae transmission. In the present report, we demonstrate that increasing the nasopharyngeal load of S. pneumoniae in the colonized index mice (via the depletion of neutrophils) and inducing a proinflammatory response in the naive cohoused contact mice (as demonstrated by cytokine production) facilitates S. pneumoniae transmission. Thus, these data provide the first insights into the factors that help mediate the spread of S. pneumoniae throughout the community. IMPORTANCE Streptococcus pneumoniae (the pneumococcus) is a major cause of worldwide morbidity and mortality and is a leading cause of death among children under the age of five years. Transmission of S. pneumoniae marks the first step toward disease development. Therefore, understanding the factors that influence the spread of pneumococci throughout the community plays an essential role in preventing pneumococcal disease. We previously developed the first reproducible infant mouse model for pneumococcal transmission and showed that coinfection with influenza virus facilitates the spread of S. pneumoniae. Here, we show that increasing the bacterial load in the nasal cavity of colonized individuals as well as inducing an inflammatory response in naive “contact cases” facilitates the spread of pneumococci. Therefore, this study helps to identify the factors which must be inhibited in order to successfully prevent pneumococcal disease.Kirsty R. ShortPatrick C. ReadingNancy WangDimitri A. DiavatopoulosOdilia L. WijburgAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 5 (2012)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Kirsty R. Short
Patrick C. Reading
Nancy Wang
Dimitri A. Diavatopoulos
Odilia L. Wijburg
Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
description ABSTRACT The transmission of the bacterium Streptococcus pneumoniae (the pneumococcus) marks the first step toward disease development. To date, our ability to prevent pneumococcal transmission has been limited by our lack of understanding regarding the factors which influence the spread of this pathogen. We have previously developed an infant mouse model of pneumococcal transmission which was strictly dependent on influenza A virus (IAV) coinfection of both the experimentally colonized “index mice” and the naive cohoused “contact mice.” Here, we sought to use this model to further elucidate the factors which facilitate S. pneumoniae transmission. In the present report, we demonstrate that increasing the nasopharyngeal load of S. pneumoniae in the colonized index mice (via the depletion of neutrophils) and inducing a proinflammatory response in the naive cohoused contact mice (as demonstrated by cytokine production) facilitates S. pneumoniae transmission. Thus, these data provide the first insights into the factors that help mediate the spread of S. pneumoniae throughout the community. IMPORTANCE Streptococcus pneumoniae (the pneumococcus) is a major cause of worldwide morbidity and mortality and is a leading cause of death among children under the age of five years. Transmission of S. pneumoniae marks the first step toward disease development. Therefore, understanding the factors that influence the spread of pneumococci throughout the community plays an essential role in preventing pneumococcal disease. We previously developed the first reproducible infant mouse model for pneumococcal transmission and showed that coinfection with influenza virus facilitates the spread of S. pneumoniae. Here, we show that increasing the bacterial load in the nasal cavity of colonized individuals as well as inducing an inflammatory response in naive “contact cases” facilitates the spread of pneumococci. Therefore, this study helps to identify the factors which must be inhibited in order to successfully prevent pneumococcal disease.
format article
author Kirsty R. Short
Patrick C. Reading
Nancy Wang
Dimitri A. Diavatopoulos
Odilia L. Wijburg
author_facet Kirsty R. Short
Patrick C. Reading
Nancy Wang
Dimitri A. Diavatopoulos
Odilia L. Wijburg
author_sort Kirsty R. Short
title Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
title_short Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
title_full Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
title_fullStr Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
title_full_unstemmed Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
title_sort increased nasopharyngeal bacterial titers and local inflammation facilitate transmission of <named-content content-type="genus-species">streptococcus pneumoniae</named-content>
publisher American Society for Microbiology
publishDate 2012
url https://doaj.org/article/5853be03136247adae08916e552db324
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