Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome

Lingyao Qi, Hanxiong Liu, Lianchao Cheng, Caiyan Cui, Xu Chen, Siqi Yang, Lin Cai Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Lin CaiDepartment of Cardiology, Affil...

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Autores principales:	Qi L, Liu H, Cheng L, Cui C, Chen X, Yang S, Cai L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	renal insufficiency acute coronary syndrome long-term prognosis retrospective study Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5854365839b8498287fcd7c30496f7e9
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spelling	oai:doaj.org-article:5854365839b8498287fcd7c30496f7e92021-11-25T18:55:29ZImpact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome1178-7074https://doaj.org/article/5854365839b8498287fcd7c30496f7e92021-11-01T00:00:00Zhttps://www.dovepress.com/impact-of-renal-insufficiency-on-prognosis-of-patients-with-acute-coro-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Lingyao Qi, Hanxiong Liu, Lianchao Cheng, Caiyan Cui, Xu Chen, Siqi Yang, Lin Cai Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Lin CaiDepartment of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, People’s Republic of ChinaTel/Fax +86 28-67575956Email clin63@hotmail.comPurpose: Chronic kidney disease (CKD) is common in patients admitted with acute coronary syndrome (ACS), and it is associated with poor outcomes. However, data are limited. Hence, we examined the long-term prognostic significance of estimated glomerular filtration rate (eGFR) among Chinese patients hospitalized with ACS.Patients and Methods: This is a multicenter, observational study that included 1860 ACS patients enrolled between March 2014 and June 2019 from 11 hospitals in Chengdu. CKD-EPI equation was used to calculate the baseline eGFR. Patients were divided into three groups: eGFR ≥ 90 mL/min (normal renal function), eGFR 60 to < 90 mL/min (mild impaired renal function), and eGFR < 60 mL/min (moderate or severe renal dysfunction). The endpoint was all-cause death during follow-up.Results: At baseline, 714 patients had normal renal function, while 746 patients had mild impaired renal function, and 400 patients had moderate or severe renal dysfunction. In the follow-up of 15 months (10 months, 22 months), 261 (14.0%) patients died;, 139 (34.8%) in the moderate or severe renal dysfunction group, 94 (12.6%) in the mild impaired renal function group, and 28 (3.9%) in the normal renal function group (log-rank p-value from Kaplan–Meier analysis < 0.001). In multivariable Cox Proportional hazard analysis, age, systolic blood pressure (SBP), heart rate, eGFR, ST-elevation myocardial infarction (STEMI), and percutaneous coronary intervention (PCI) were independent predictors of all-cause death.Conclusion: In this study, among Chinese patients with ACS, renal insufficiency was associated with unfavorable long-term prognosis. Age, SBP, heart rate, eGFR, STEMI, and PCI could identify those at risk.Keywords: renal insufficiency, acute coronary syndrome, long-term prognosis, retrospective studyQi LLiu HCheng LCui CChen XYang SCai LDove Medical Pressarticlerenal insufficiencyacute coronary syndromelong-term prognosisretrospective studyMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8919-8927 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal insufficiency acute coronary syndrome long-term prognosis retrospective study Medicine (General) R5-920
spellingShingle	renal insufficiency acute coronary syndrome long-term prognosis retrospective study Medicine (General) R5-920 Qi L Liu H Cheng L Cui C Chen X Yang S Cai L Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome
description	Lingyao Qi, Hanxiong Liu, Lianchao Cheng, Caiyan Cui, Xu Chen, Siqi Yang, Lin Cai Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Lin CaiDepartment of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, People’s Republic of ChinaTel/Fax +86 28-67575956Email clin63@hotmail.comPurpose: Chronic kidney disease (CKD) is common in patients admitted with acute coronary syndrome (ACS), and it is associated with poor outcomes. However, data are limited. Hence, we examined the long-term prognostic significance of estimated glomerular filtration rate (eGFR) among Chinese patients hospitalized with ACS.Patients and Methods: This is a multicenter, observational study that included 1860 ACS patients enrolled between March 2014 and June 2019 from 11 hospitals in Chengdu. CKD-EPI equation was used to calculate the baseline eGFR. Patients were divided into three groups: eGFR ≥ 90 mL/min (normal renal function), eGFR 60 to < 90 mL/min (mild impaired renal function), and eGFR < 60 mL/min (moderate or severe renal dysfunction). The endpoint was all-cause death during follow-up.Results: At baseline, 714 patients had normal renal function, while 746 patients had mild impaired renal function, and 400 patients had moderate or severe renal dysfunction. In the follow-up of 15 months (10 months, 22 months), 261 (14.0%) patients died;, 139 (34.8%) in the moderate or severe renal dysfunction group, 94 (12.6%) in the mild impaired renal function group, and 28 (3.9%) in the normal renal function group (log-rank p-value from Kaplan–Meier analysis < 0.001). In multivariable Cox Proportional hazard analysis, age, systolic blood pressure (SBP), heart rate, eGFR, ST-elevation myocardial infarction (STEMI), and percutaneous coronary intervention (PCI) were independent predictors of all-cause death.Conclusion: In this study, among Chinese patients with ACS, renal insufficiency was associated with unfavorable long-term prognosis. Age, SBP, heart rate, eGFR, STEMI, and PCI could identify those at risk.Keywords: renal insufficiency, acute coronary syndrome, long-term prognosis, retrospective study
format	article
author	Qi L Liu H Cheng L Cui C Chen X Yang S Cai L
author_facet	Qi L Liu H Cheng L Cui C Chen X Yang S Cai L
author_sort	Qi L
title	Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome
title_short	Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome
title_full	Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome
title_fullStr	Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome
title_full_unstemmed	Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome
title_sort	impact of renal insufficiency on prognosis of patients with acute coronary syndrome
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5854365839b8498287fcd7c30496f7e9
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Impact of Renal Insufficiency on Prognosis of Patients with Acute Coronary Syndrome

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