Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Spliceosome mutations occur in approximately 50% of patients with myelodysplastic syndromes. Here, the authors show that tumour cells harbouring theS34F mutation in the U2AFspliceosome gene is sensitive to compounds that further perturb the spliceosome.

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Autores principales:	Cara Lunn Shirai, Brian S. White, Manorama Tripathi, Roberto Tapia, James N. Ley, Matthew Ndonwi, Sanghyun Kim, Jin Shao, Alexa Carver, Borja Saez, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Chandraiah Lagisetti, Thomas R. Webb, Timothy A. Graubert, Matthew J. Walter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58561889db084efca98a8125161aeb78
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spelling	oai:doaj.org-article:58561889db084efca98a8125161aeb782021-12-02T15:38:51ZMutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome10.1038/ncomms140602041-1723https://doaj.org/article/58561889db084efca98a8125161aeb782017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14060https://doaj.org/toc/2041-1723Spliceosome mutations occur in approximately 50% of patients with myelodysplastic syndromes. Here, the authors show that tumour cells harbouring theS34F mutation in the U2AFspliceosome gene is sensitive to compounds that further perturb the spliceosome.Cara Lunn ShiraiBrian S. WhiteManorama TripathiRoberto TapiaJames N. LeyMatthew NdonwiSanghyun KimJin ShaoAlexa CarverBorja SaezRobert S. FultonCatrina FronickMichelle O’LaughlinChandraiah LagisettiThomas R. WebbTimothy A. GraubertMatthew J. WalterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cara Lunn Shirai Brian S. White Manorama Tripathi Roberto Tapia James N. Ley Matthew Ndonwi Sanghyun Kim Jin Shao Alexa Carver Borja Saez Robert S. Fulton Catrina Fronick Michelle O’Laughlin Chandraiah Lagisetti Thomas R. Webb Timothy A. Graubert Matthew J. Walter Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
description	Spliceosome mutations occur in approximately 50% of patients with myelodysplastic syndromes. Here, the authors show that tumour cells harbouring theS34F mutation in the U2AFspliceosome gene is sensitive to compounds that further perturb the spliceosome.
format	article
author	Cara Lunn Shirai Brian S. White Manorama Tripathi Roberto Tapia James N. Ley Matthew Ndonwi Sanghyun Kim Jin Shao Alexa Carver Borja Saez Robert S. Fulton Catrina Fronick Michelle O’Laughlin Chandraiah Lagisetti Thomas R. Webb Timothy A. Graubert Matthew J. Walter
author_facet	Cara Lunn Shirai Brian S. White Manorama Tripathi Roberto Tapia James N. Ley Matthew Ndonwi Sanghyun Kim Jin Shao Alexa Carver Borja Saez Robert S. Fulton Catrina Fronick Michelle O’Laughlin Chandraiah Lagisetti Thomas R. Webb Timothy A. Graubert Matthew J. Walter
author_sort	Cara Lunn Shirai
title	Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
title_short	Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
title_full	Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
title_fullStr	Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
title_full_unstemmed	Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
title_sort	mutant u2af1-expressing cells are sensitive to pharmacological modulation of the spliceosome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/58561889db084efca98a8125161aeb78
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Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

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