CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.

CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.

The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein complexes responsible for activation of caspase-1, a regulator of inflammation and innate immunity. Although identified many yea...

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Autores principales: Andrea D'Osualdo, Christian X Weichenberger, Roland N Wagner, Adam Godzik, John Wooley, John C Reed
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/58570e84f44541c89c521a4dd5f68504
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