Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache

BACKGROUND AND OBJECTIVE: Migraine is a chronic neurological disorder and it leads patients to avoid any kind of activity. Since different factors are involved in migraine incidence and its triggers, a wide variety of drugs are used to prevent or treat. Combination therapy has shown its efficiency i...

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Autores principales:	M Baradaran, A M, Ahmadi Ahangar, F Teymourian, F Alinezhad, AA Moghadamnia
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	migraine ibuprofen alprazolam nonsteroidal antiinflammatory drugs (nsaids) benzodiazepines combination therapy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5858024041124c6eabf4b09f851e34ca
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spelling	oai:doaj.org-article:5858024041124c6eabf4b09f851e34ca2021-11-10T08:56:34ZConcomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache1561-41072251-7170https://doaj.org/article/5858024041124c6eabf4b09f851e34ca2011-05-01T00:00:00Zhttp://jbums.org/article-1-3798-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Migraine is a chronic neurological disorder and it leads patients to avoid any kind of activity. Since different factors are involved in migraine incidence and its triggers, a wide variety of drugs are used to prevent or treat. Combination therapy has shown its efficiency in treating migraine. In this study, we have taken the combination of ibuprofen and alprazolam as a probable efficient compound in reducing these headaches. METHODS: In this clinical trial study, 90 migraine patients were allocated in 3 groups of 30, with an average of 2-6 attacks in month underwent. These three groups were unified by age, gender and their drug histories. After receiving volunteer’s adhesion for taking part in this experiment, the first group were given a single dose of ibuprofen 200 mg, the second group were given a single dose of ibuprofen 400 mg and the third group were given a single dose of ibuprofen 200 mg in companion with alprazolam 0.5 mg. Headache severity, functional disability and associated symptoms of the patients were recorded before and two hours after taking each regimen and were graded from 0-3 points. Then three groups were compared. FINDINGS: In all 3 groups, the severity of the headaches were reduced significantly after the course of drug therapy with 36% of reduction in the first group, 46% in the second group, and 74% in the third group, respectively (p<0.0001). In the first group, nausea and vomiting were reduced from 92.3% to 22.3%, the second group from 96.7% to 13.3% and, finally the third group from 100% to 3.3% (p<0.0001). In addition, a significant reduction in photophobia and phonophobia was seen before and after taking the drugs (p<0.0001). CONCLUSION: The combination of ibuprofen 200 mg and alprazolam 0.5 mg had significantly reduced the severity of the migraine headaches.M BaradaranA M, Ahmadi AhangarF TeymourianF AlinezhadAA MoghadamniaBabol University of Medical Sciencesarticlemigraineibuprofenalprazolamnonsteroidal antiinflammatory drugs (nsaids)benzodiazepinescombination therapyMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 3, Pp 15-21 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	migraine ibuprofen alprazolam nonsteroidal antiinflammatory drugs (nsaids) benzodiazepines combination therapy Medicine R Medicine (General) R5-920
spellingShingle	migraine ibuprofen alprazolam nonsteroidal antiinflammatory drugs (nsaids) benzodiazepines combination therapy Medicine R Medicine (General) R5-920 M Baradaran A M, Ahmadi Ahangar F Teymourian F Alinezhad AA Moghadamnia Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache
description	BACKGROUND AND OBJECTIVE: Migraine is a chronic neurological disorder and it leads patients to avoid any kind of activity. Since different factors are involved in migraine incidence and its triggers, a wide variety of drugs are used to prevent or treat. Combination therapy has shown its efficiency in treating migraine. In this study, we have taken the combination of ibuprofen and alprazolam as a probable efficient compound in reducing these headaches. METHODS: In this clinical trial study, 90 migraine patients were allocated in 3 groups of 30, with an average of 2-6 attacks in month underwent. These three groups were unified by age, gender and their drug histories. After receiving volunteer’s adhesion for taking part in this experiment, the first group were given a single dose of ibuprofen 200 mg, the second group were given a single dose of ibuprofen 400 mg and the third group were given a single dose of ibuprofen 200 mg in companion with alprazolam 0.5 mg. Headache severity, functional disability and associated symptoms of the patients were recorded before and two hours after taking each regimen and were graded from 0-3 points. Then three groups were compared. FINDINGS: In all 3 groups, the severity of the headaches were reduced significantly after the course of drug therapy with 36% of reduction in the first group, 46% in the second group, and 74% in the third group, respectively (p<0.0001). In the first group, nausea and vomiting were reduced from 92.3% to 22.3%, the second group from 96.7% to 13.3% and, finally the third group from 100% to 3.3% (p<0.0001). In addition, a significant reduction in photophobia and phonophobia was seen before and after taking the drugs (p<0.0001). CONCLUSION: The combination of ibuprofen 200 mg and alprazolam 0.5 mg had significantly reduced the severity of the migraine headaches.
format	article
author	M Baradaran A M, Ahmadi Ahangar F Teymourian F Alinezhad AA Moghadamnia
author_facet	M Baradaran A M, Ahmadi Ahangar F Teymourian F Alinezhad AA Moghadamnia
author_sort	M Baradaran
title	Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache
title_short	Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache
title_full	Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache
title_fullStr	Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache
title_full_unstemmed	Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache
title_sort	concomitant administration of alprazolam and ibuprofen in acute migraine headache
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/5858024041124c6eabf4b09f851e34ca
work_keys_str_mv	AT mbaradaran concomitantadministrationofalprazolamandibuprofeninacutemigraineheadache AT amahmadiahangar concomitantadministrationofalprazolamandibuprofeninacutemigraineheadache AT fteymourian concomitantadministrationofalprazolamandibuprofeninacutemigraineheadache AT falinezhad concomitantadministrationofalprazolamandibuprofeninacutemigraineheadache AT aamoghadamnia concomitantadministrationofalprazolamandibuprofeninacutemigraineheadache
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Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache

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