Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular disse...
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Nature Portfolio
2018
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oai:doaj.org-article:5859dcee62b843f5bc95e474b541df8d2021-12-02T14:40:55ZCytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling10.1038/s41467-018-07660-62041-1723https://doaj.org/article/5859dcee62b843f5bc95e474b541df8d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07660-6https://doaj.org/toc/2041-1723Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular dissemination via the YAP1-FAK/PXN axis.Shu-Chen LiuTien HsuYu-Sun ChangAn-Ko ChungShih Sheng JiangChun-Nan OuYangChiou-Hwa YuhChuen HsuehYa-Ping LiuNgan-Ming TsangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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Science Q Shu-Chen Liu Tien Hsu Yu-Sun Chang An-Ko Chung Shih Sheng Jiang Chun-Nan OuYang Chiou-Hwa Yuh Chuen Hsueh Ya-Ping Liu Ngan-Ming Tsang Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling |
description |
Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular dissemination via the YAP1-FAK/PXN axis. |
format |
article |
author |
Shu-Chen Liu Tien Hsu Yu-Sun Chang An-Ko Chung Shih Sheng Jiang Chun-Nan OuYang Chiou-Hwa Yuh Chuen Hsueh Ya-Ping Liu Ngan-Ming Tsang |
author_facet |
Shu-Chen Liu Tien Hsu Yu-Sun Chang An-Ko Chung Shih Sheng Jiang Chun-Nan OuYang Chiou-Hwa Yuh Chuen Hsueh Ya-Ping Liu Ngan-Ming Tsang |
author_sort |
Shu-Chen Liu |
title |
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling |
title_short |
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling |
title_full |
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling |
title_fullStr |
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling |
title_full_unstemmed |
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling |
title_sort |
cytoplasmic lif reprograms invasive mode to enhance npc dissemination through modulating yap1-fak/pxn signaling |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/5859dcee62b843f5bc95e474b541df8d |
work_keys_str_mv |
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