Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain

While prime editing is a promising technology, PE2 systems often have low efficiency. Here the authors fuse a Rad51 DNA-binding domain to create hyPE2 with improved editing efficiency.

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Autores principales:	Myungjae Song, Jung Min Lim, Seonwoo Min, Jeong-Seok Oh, Dong Young Kim, Jae-Sung Woo, Hiroshi Nishimasu, Sung-Rae Cho, Sungroh Yoon, Hyongbum Henry Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/585d27be31a74bf5926e523fa4034081
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spelling	oai:doaj.org-article:585d27be31a74bf5926e523fa40340812021-12-02T18:14:31ZGeneration of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain10.1038/s41467-021-25928-22041-1723https://doaj.org/article/585d27be31a74bf5926e523fa40340812021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25928-2https://doaj.org/toc/2041-1723While prime editing is a promising technology, PE2 systems often have low efficiency. Here the authors fuse a Rad51 DNA-binding domain to create hyPE2 with improved editing efficiency.Myungjae SongJung Min LimSeonwoo MinJeong-Seok OhDong Young KimJae-Sung WooHiroshi NishimasuSung-Rae ChoSungroh YoonHyongbum Henry KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myungjae Song Jung Min Lim Seonwoo Min Jeong-Seok Oh Dong Young Kim Jae-Sung Woo Hiroshi Nishimasu Sung-Rae Cho Sungroh Yoon Hyongbum Henry Kim Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
description	While prime editing is a promising technology, PE2 systems often have low efficiency. Here the authors fuse a Rad51 DNA-binding domain to create hyPE2 with improved editing efficiency.
format	article
author	Myungjae Song Jung Min Lim Seonwoo Min Jeong-Seok Oh Dong Young Kim Jae-Sung Woo Hiroshi Nishimasu Sung-Rae Cho Sungroh Yoon Hyongbum Henry Kim
author_facet	Myungjae Song Jung Min Lim Seonwoo Min Jeong-Seok Oh Dong Young Kim Jae-Sung Woo Hiroshi Nishimasu Sung-Rae Cho Sungroh Yoon Hyongbum Henry Kim
author_sort	Myungjae Song
title	Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
title_short	Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
title_full	Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
title_fullStr	Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
title_full_unstemmed	Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
title_sort	generation of a more efficient prime editor 2 by addition of the rad51 dna-binding domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/585d27be31a74bf5926e523fa4034081
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Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain

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