Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress

Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease worldwide, and is frequently linked to the metabolic syndrome. The latter represents a clustering of related cardio-metabolic components, which are often observed in patients with NAFLD and increase the risk of cardi...

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Autores principales:	Sue Shea, Christos Lionis, Chris Kite, Lou Atkinson, Surinderjeet S. Chaggar, Harpal S. Randeva, Ioannis Kyrou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-alcoholic fatty liver disease NAFLD NASH metabolic syndrome insulin resistance obesity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5860547aea9e4ee9a5effc8cee9f7d89
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spelling	oai:doaj.org-article:5860547aea9e4ee9a5effc8cee9f7d892021-11-25T16:50:56ZNon-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress10.3390/biomedicines91116972227-9059https://doaj.org/article/5860547aea9e4ee9a5effc8cee9f7d892021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1697https://doaj.org/toc/2227-9059Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease worldwide, and is frequently linked to the metabolic syndrome. The latter represents a clustering of related cardio-metabolic components, which are often observed in patients with NAFLD and increase the risk of cardiovascular disease. Furthermore, growing evidence suggests a positive association between metabolic syndrome and certain mental health problems (e.g., depression, anxiety, and chronic stress). Given the strong overlap between metabolic syndrome and NAFLD, and the common underlying mechanisms that link the two conditions, it is probable that potentially bidirectional associations are also present between NAFLD and mental health comorbidity. The identification of such links is worthy of further investigation, as this can inform more targeted interventions for patients with NAFLD. Therefore, the present review discusses published evidence in relation to associations of depression, anxiety, stress, and impaired health-related quality of life with NAFLD and metabolic syndrome. Attention is also drawn to the complex nature of affective disorders and potential overlapping symptoms between such conditions and NAFLD, while a focus is also placed on the postulated mechanisms mediating associations between mental health and both NAFLD and metabolic syndrome. Relevant gaps/weaknesses of the available literature are also highlighted, together with future research directions that need to be further explored.Sue SheaChristos LionisChris KiteLou AtkinsonSurinderjeet S. ChaggarHarpal S. RandevaIoannis KyrouMDPI AGarticlenon-alcoholic fatty liver diseaseNAFLDNASHmetabolic syndromeinsulin resistanceobesityBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1697, p 1697 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic fatty liver disease NAFLD NASH metabolic syndrome insulin resistance obesity Biology (General) QH301-705.5
spellingShingle	non-alcoholic fatty liver disease NAFLD NASH metabolic syndrome insulin resistance obesity Biology (General) QH301-705.5 Sue Shea Christos Lionis Chris Kite Lou Atkinson Surinderjeet S. Chaggar Harpal S. Randeva Ioannis Kyrou Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress
description	Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease worldwide, and is frequently linked to the metabolic syndrome. The latter represents a clustering of related cardio-metabolic components, which are often observed in patients with NAFLD and increase the risk of cardiovascular disease. Furthermore, growing evidence suggests a positive association between metabolic syndrome and certain mental health problems (e.g., depression, anxiety, and chronic stress). Given the strong overlap between metabolic syndrome and NAFLD, and the common underlying mechanisms that link the two conditions, it is probable that potentially bidirectional associations are also present between NAFLD and mental health comorbidity. The identification of such links is worthy of further investigation, as this can inform more targeted interventions for patients with NAFLD. Therefore, the present review discusses published evidence in relation to associations of depression, anxiety, stress, and impaired health-related quality of life with NAFLD and metabolic syndrome. Attention is also drawn to the complex nature of affective disorders and potential overlapping symptoms between such conditions and NAFLD, while a focus is also placed on the postulated mechanisms mediating associations between mental health and both NAFLD and metabolic syndrome. Relevant gaps/weaknesses of the available literature are also highlighted, together with future research directions that need to be further explored.
format	article
author	Sue Shea Christos Lionis Chris Kite Lou Atkinson Surinderjeet S. Chaggar Harpal S. Randeva Ioannis Kyrou
author_facet	Sue Shea Christos Lionis Chris Kite Lou Atkinson Surinderjeet S. Chaggar Harpal S. Randeva Ioannis Kyrou
author_sort	Sue Shea
title	Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress
title_short	Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress
title_full	Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress
title_fullStr	Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress
title_full_unstemmed	Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress
title_sort	non-alcoholic fatty liver disease (nafld) and potential links to depression, anxiety, and chronic stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5860547aea9e4ee9a5effc8cee9f7d89
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Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress

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