Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses

Abstract A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207...

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Autores principales:	Manuela Buonanno, David Welch, Igor Shuryak, David J. Brenner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58630de7c3b347c4a90412adf796a247
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spelling	oai:doaj.org-article:58630de7c3b347c4a90412adf796a2472021-12-02T17:45:04ZFar-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses10.1038/s41598-020-67211-22045-2322https://doaj.org/article/58630de7c3b347c4a90412adf796a2472020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67211-2https://doaj.org/toc/2045-2322Abstract A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207–222 nm) efficiently kills pathogens potentially without harm to exposed human tissues. We previously demonstrated that 222-nm far-UVC light efficiently kills airborne influenza virus and we extend those studies to explore far-UVC efficacy against airborne human coronaviruses alpha HCoV-229E and beta HCoV-OC43. Low doses of 1.7 and 1.2 mJ/cm2 inactivated 99.9% of aerosolized coronavirus 229E and OC43, respectively. As all human coronaviruses have similar genomic sizes, far-UVC light would be expected to show similar inactivation efficiency against other human coronaviruses including SARS-CoV-2. Based on the beta-HCoV-OC43 results, continuous far-UVC exposure in occupied public locations at the current regulatory exposure limit (~3 mJ/cm2/hour) would result in ~90% viral inactivation in ~8 minutes, 95% in ~11 minutes, 99% in ~16 minutes and 99.9% inactivation in ~25 minutes. Thus while staying within current regulatory dose limits, low-dose-rate far-UVC exposure can potentially safely provide a major reduction in the ambient level of airborne coronaviruses in occupied public locations.Manuela BuonannoDavid WelchIgor ShuryakDavid J. BrennerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manuela Buonanno David Welch Igor Shuryak David J. Brenner Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
description	Abstract A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207–222 nm) efficiently kills pathogens potentially without harm to exposed human tissues. We previously demonstrated that 222-nm far-UVC light efficiently kills airborne influenza virus and we extend those studies to explore far-UVC efficacy against airborne human coronaviruses alpha HCoV-229E and beta HCoV-OC43. Low doses of 1.7 and 1.2 mJ/cm2 inactivated 99.9% of aerosolized coronavirus 229E and OC43, respectively. As all human coronaviruses have similar genomic sizes, far-UVC light would be expected to show similar inactivation efficiency against other human coronaviruses including SARS-CoV-2. Based on the beta-HCoV-OC43 results, continuous far-UVC exposure in occupied public locations at the current regulatory exposure limit (~3 mJ/cm2/hour) would result in ~90% viral inactivation in ~8 minutes, 95% in ~11 minutes, 99% in ~16 minutes and 99.9% inactivation in ~25 minutes. Thus while staying within current regulatory dose limits, low-dose-rate far-UVC exposure can potentially safely provide a major reduction in the ambient level of airborne coronaviruses in occupied public locations.
format	article
author	Manuela Buonanno David Welch Igor Shuryak David J. Brenner
author_facet	Manuela Buonanno David Welch Igor Shuryak David J. Brenner
author_sort	Manuela Buonanno
title	Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
title_short	Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
title_full	Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
title_fullStr	Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
title_full_unstemmed	Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
title_sort	far-uvc light (222 nm) efficiently and safely inactivates airborne human coronaviruses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/58630de7c3b347c4a90412adf796a247
work_keys_str_mv	AT manuelabuonanno faruvclight222nmefficientlyandsafelyinactivatesairbornehumancoronaviruses AT davidwelch faruvclight222nmefficientlyandsafelyinactivatesairbornehumancoronaviruses AT igorshuryak faruvclight222nmefficientlyandsafelyinactivatesairbornehumancoronaviruses AT davidjbrenner faruvclight222nmefficientlyandsafelyinactivatesairbornehumancoronaviruses
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Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses

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