Redox-enabled direct stereoconvergent heteroarylation of simple alcohols

Synthesizing complex structures of high enantiomeric excess from racemic feedstock is an enduring challenge. Here, the authors couple racemic secondary alcohols with pyrroles to form enantioenriched 2-substituted heteroarenes, via a borrowing hydrogen mechanism using the combination of an iridium ca...

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Autores principales:	Yongbing Liu, Ran Tao, Zhi-Keng Lin, Guoqiang Yang, Yu Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5867112204c34ed884100fac0f8cb366
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spelling	oai:doaj.org-article:5867112204c34ed884100fac0f8cb3662021-12-02T17:08:26ZRedox-enabled direct stereoconvergent heteroarylation of simple alcohols10.1038/s41467-021-25268-12041-1723https://doaj.org/article/5867112204c34ed884100fac0f8cb3662021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25268-1https://doaj.org/toc/2041-1723Synthesizing complex structures of high enantiomeric excess from racemic feedstock is an enduring challenge. Here, the authors couple racemic secondary alcohols with pyrroles to form enantioenriched 2-substituted heteroarenes, via a borrowing hydrogen mechanism using the combination of an iridium catalyst and chiral phosphoric acid.Yongbing LiuRan TaoZhi-Keng LinGuoqiang YangYu ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongbing Liu Ran Tao Zhi-Keng Lin Guoqiang Yang Yu Zhao Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
description	Synthesizing complex structures of high enantiomeric excess from racemic feedstock is an enduring challenge. Here, the authors couple racemic secondary alcohols with pyrroles to form enantioenriched 2-substituted heteroarenes, via a borrowing hydrogen mechanism using the combination of an iridium catalyst and chiral phosphoric acid.
format	article
author	Yongbing Liu Ran Tao Zhi-Keng Lin Guoqiang Yang Yu Zhao
author_facet	Yongbing Liu Ran Tao Zhi-Keng Lin Guoqiang Yang Yu Zhao
author_sort	Yongbing Liu
title	Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
title_short	Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
title_full	Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
title_fullStr	Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
title_full_unstemmed	Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
title_sort	redox-enabled direct stereoconvergent heteroarylation of simple alcohols
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5867112204c34ed884100fac0f8cb366
work_keys_str_mv	AT yongbingliu redoxenableddirectstereoconvergentheteroarylationofsimplealcohols AT rantao redoxenableddirectstereoconvergentheteroarylationofsimplealcohols AT zhikenglin redoxenableddirectstereoconvergentheteroarylationofsimplealcohols AT guoqiangyang redoxenableddirectstereoconvergentheteroarylationofsimplealcohols AT yuzhao redoxenableddirectstereoconvergentheteroarylationofsimplealcohols
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Redox-enabled direct stereoconvergent heteroarylation of simple alcohols

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