Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
Abstract Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of int...
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2019
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oai:doaj.org-article:586a0ec07bae48f3a405cae15704b7602021-12-02T15:08:10ZEvaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake10.1038/s41598-019-49702-z2045-2322https://doaj.org/article/586a0ec07bae48f3a405cae15704b7602019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49702-zhttps://doaj.org/toc/2045-2322Abstract Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (−)-epicatechin metabolites (SREM), particularly (−)-epicatechin-3′-glucuronide, (−)-epicatechin-3′-sulfate and 3′-O-methyl-(−)-epicatechin-5-sulfate (SREMB), as flavan-3-ol and (−)-epicatechin intake. SREMB in urine proved to be a specific indicator of (−)-epicatechin intake, showing also a strong correlation with the amount of (−)-epicatechin ingested (R2: 0.86 (95% CI 0.8l; 0.92). The median recovery of (−)-epicatechin as SREMB in 24 h urine was 10% (IQR 7–13%) and we found SREMB in the majority of participants of EPIC Norfolk (83% of 24,341) with a mean concentration of 2.4 ± 3.2 µmol/L. Our results show that SREMB are suitable as biomarker of (−)-epicatechin intake. According to evaluation criteria from IARC and the Institute of Medicine, the results obtained support use of SREMB as a recovery biomarker to estimate actual intake of (−)-epicatechin.Javier I. OttavianiReedmond FongJennifer KimballJodi L. EnsunsaNicola GrayAnna VogiatzoglouAbigail BrittenDebora LucarelliRobert LubenPhilip B. GraceDeborah H. MawsonAmy TymAntonia WierzbickiA. David SmithNicholas J. WarehamNita G. ForouhiKay-Tee KhawHagen SchroeterGunter G. C. KuhnleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
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Medicine R Science Q Javier I. Ottaviani Reedmond Fong Jennifer Kimball Jodi L. Ensunsa Nicola Gray Anna Vogiatzoglou Abigail Britten Debora Lucarelli Robert Luben Philip B. Grace Deborah H. Mawson Amy Tym Antonia Wierzbicki A. David Smith Nicholas J. Wareham Nita G. Forouhi Kay-Tee Khaw Hagen Schroeter Gunter G. C. Kuhnle Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| description |
Abstract Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (−)-epicatechin metabolites (SREM), particularly (−)-epicatechin-3′-glucuronide, (−)-epicatechin-3′-sulfate and 3′-O-methyl-(−)-epicatechin-5-sulfate (SREMB), as flavan-3-ol and (−)-epicatechin intake. SREMB in urine proved to be a specific indicator of (−)-epicatechin intake, showing also a strong correlation with the amount of (−)-epicatechin ingested (R2: 0.86 (95% CI 0.8l; 0.92). The median recovery of (−)-epicatechin as SREMB in 24 h urine was 10% (IQR 7–13%) and we found SREMB in the majority of participants of EPIC Norfolk (83% of 24,341) with a mean concentration of 2.4 ± 3.2 µmol/L. Our results show that SREMB are suitable as biomarker of (−)-epicatechin intake. According to evaluation criteria from IARC and the Institute of Medicine, the results obtained support use of SREMB as a recovery biomarker to estimate actual intake of (−)-epicatechin. |
| format |
article |
| author |
Javier I. Ottaviani Reedmond Fong Jennifer Kimball Jodi L. Ensunsa Nicola Gray Anna Vogiatzoglou Abigail Britten Debora Lucarelli Robert Luben Philip B. Grace Deborah H. Mawson Amy Tym Antonia Wierzbicki A. David Smith Nicholas J. Wareham Nita G. Forouhi Kay-Tee Khaw Hagen Schroeter Gunter G. C. Kuhnle |
| author_facet |
Javier I. Ottaviani Reedmond Fong Jennifer Kimball Jodi L. Ensunsa Nicola Gray Anna Vogiatzoglou Abigail Britten Debora Lucarelli Robert Luben Philip B. Grace Deborah H. Mawson Amy Tym Antonia Wierzbicki A. David Smith Nicholas J. Wareham Nita G. Forouhi Kay-Tee Khaw Hagen Schroeter Gunter G. C. Kuhnle |
| author_sort |
Javier I. Ottaviani |
| title |
Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| title_short |
Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| title_full |
Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| title_fullStr |
Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| title_full_unstemmed |
Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| title_sort |
evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/586a0ec07bae48f3a405cae15704b760 |
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