KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression

RNA-binding proteins (RBPs) regulate RNA activity and are implicated in haematopoietic malignancies, but their role in myeloid cell specification is unclear. Here, the authors show a role for the RBP KSRP in promoting granulocyte fate over monocyte fate through the biogenesis of miR-129 and a decrea...

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Autores principales:	Hongmei Zhao, Xiaoshuang Wang, Ping Yi, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang, Fang Wang, Jia Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/586a17f8c724437aa01e460706e234b2
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spelling	oai:doaj.org-article:586a17f8c724437aa01e460706e234b22021-12-02T14:40:25ZKSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression10.1038/s41467-017-01425-32041-1723https://doaj.org/article/586a17f8c724437aa01e460706e234b22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01425-3https://doaj.org/toc/2041-1723RNA-binding proteins (RBPs) regulate RNA activity and are implicated in haematopoietic malignancies, but their role in myeloid cell specification is unclear. Here, the authors show a role for the RBP KSRP in promoting granulocyte fate over monocyte fate through the biogenesis of miR-129 and a decrease in RUNX1.Hongmei ZhaoXiaoshuang WangPing YiYanmin SiPuwen TanJinrong HeShan YuYue RenYanni MaJunwu ZhangDong WangFang WangJia YuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongmei Zhao Xiaoshuang Wang Ping Yi Yanmin Si Puwen Tan Jinrong He Shan Yu Yue Ren Yanni Ma Junwu Zhang Dong Wang Fang Wang Jia Yu KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
description	RNA-binding proteins (RBPs) regulate RNA activity and are implicated in haematopoietic malignancies, but their role in myeloid cell specification is unclear. Here, the authors show a role for the RBP KSRP in promoting granulocyte fate over monocyte fate through the biogenesis of miR-129 and a decrease in RUNX1.
format	article
author	Hongmei Zhao Xiaoshuang Wang Ping Yi Yanmin Si Puwen Tan Jinrong He Shan Yu Yue Ren Yanni Ma Junwu Zhang Dong Wang Fang Wang Jia Yu
author_facet	Hongmei Zhao Xiaoshuang Wang Ping Yi Yanmin Si Puwen Tan Jinrong He Shan Yu Yue Ren Yanni Ma Junwu Zhang Dong Wang Fang Wang Jia Yu
author_sort	Hongmei Zhao
title	KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
title_short	KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
title_full	KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
title_fullStr	KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
title_full_unstemmed	KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
title_sort	ksrp specifies monocytic and granulocytic differentiation through regulating mir-129 biogenesis and runx1 expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/586a17f8c724437aa01e460706e234b2
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KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression

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