Herbicidal properties of antihypertensive drugs: calcium channel blockers

Abstract Herbicide resistance is a worldwide problem in weed control. This prompts researchers to look for new modes of action to slow down the evolution of herbicide-resistant weeds. This research aims to determine the herbicidal action of thiazolo[3,2-a]pyrimidines derivatives, which are well know...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hannan Safiyyah Tan Sian Hui Abdullah, Poh Wai Chia, Dzolkhifli Omar, Tse Seng Chuah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/586efefc3b1d4375b61eff93ca71e59d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:586efefc3b1d4375b61eff93ca71e59d
record_format	dspace
spelling	oai:doaj.org-article:586efefc3b1d4375b61eff93ca71e59d2021-12-02T16:15:06ZHerbicidal properties of antihypertensive drugs: calcium channel blockers10.1038/s41598-021-93662-22045-2322https://doaj.org/article/586efefc3b1d4375b61eff93ca71e59d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93662-2https://doaj.org/toc/2045-2322Abstract Herbicide resistance is a worldwide problem in weed control. This prompts researchers to look for new modes of action to slow down the evolution of herbicide-resistant weeds. This research aims to determine the herbicidal action of thiazolo[3,2-a]pyrimidines derivatives, which are well known as antihypertensive drugs. The phytotoxic effects of ten compounds were investigated using leaf disc discoloration test and seed germination bioassay. At concentrations of 125 to 250 mg/L, the 5-(3-Fluoro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester (c) was highly active against Oldenlandia verticillata and Eleusine indica. At application rates of 1.25 to 2.5 kg ai/ha, formulated c demonstrated selective post-emergence and pre-emergence herbicidal activity against O. verticillata, E. indica and Cyperus iria. In the crop tolerance test, formulated c outperformed the commercial herbicide diuron, with aerobic Oryza sativa being the most tolerant, followed by Zea mays, and Brassica rapa. The addition of calcium chloride partially nullified compound c's inhibitory effects on weed shoot growth, indicating that it has potential as a calcium channel blocker. Compound c acted by triggering electrolyte leakage without affecting photosystem II. These findings imply that c could be explored further as a template for developing new herbicides with novel modes of action.Hannan Safiyyah Tan Sian Hui AbdullahPoh Wai ChiaDzolkhifli OmarTse Seng ChuahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hannan Safiyyah Tan Sian Hui Abdullah Poh Wai Chia Dzolkhifli Omar Tse Seng Chuah Herbicidal properties of antihypertensive drugs: calcium channel blockers
description	Abstract Herbicide resistance is a worldwide problem in weed control. This prompts researchers to look for new modes of action to slow down the evolution of herbicide-resistant weeds. This research aims to determine the herbicidal action of thiazolo[3,2-a]pyrimidines derivatives, which are well known as antihypertensive drugs. The phytotoxic effects of ten compounds were investigated using leaf disc discoloration test and seed germination bioassay. At concentrations of 125 to 250 mg/L, the 5-(3-Fluoro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester (c) was highly active against Oldenlandia verticillata and Eleusine indica. At application rates of 1.25 to 2.5 kg ai/ha, formulated c demonstrated selective post-emergence and pre-emergence herbicidal activity against O. verticillata, E. indica and Cyperus iria. In the crop tolerance test, formulated c outperformed the commercial herbicide diuron, with aerobic Oryza sativa being the most tolerant, followed by Zea mays, and Brassica rapa. The addition of calcium chloride partially nullified compound c's inhibitory effects on weed shoot growth, indicating that it has potential as a calcium channel blocker. Compound c acted by triggering electrolyte leakage without affecting photosystem II. These findings imply that c could be explored further as a template for developing new herbicides with novel modes of action.
format	article
author	Hannan Safiyyah Tan Sian Hui Abdullah Poh Wai Chia Dzolkhifli Omar Tse Seng Chuah
author_facet	Hannan Safiyyah Tan Sian Hui Abdullah Poh Wai Chia Dzolkhifli Omar Tse Seng Chuah
author_sort	Hannan Safiyyah Tan Sian Hui Abdullah
title	Herbicidal properties of antihypertensive drugs: calcium channel blockers
title_short	Herbicidal properties of antihypertensive drugs: calcium channel blockers
title_full	Herbicidal properties of antihypertensive drugs: calcium channel blockers
title_fullStr	Herbicidal properties of antihypertensive drugs: calcium channel blockers
title_full_unstemmed	Herbicidal properties of antihypertensive drugs: calcium channel blockers
title_sort	herbicidal properties of antihypertensive drugs: calcium channel blockers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/586efefc3b1d4375b61eff93ca71e59d
work_keys_str_mv	AT hannansafiyyahtansianhuiabdullah herbicidalpropertiesofantihypertensivedrugscalciumchannelblockers AT pohwaichia herbicidalpropertiesofantihypertensivedrugscalciumchannelblockers AT dzolkhifliomar herbicidalpropertiesofantihypertensivedrugscalciumchannelblockers AT tsesengchuah herbicidalpropertiesofantihypertensivedrugscalciumchannelblockers
_version_	1718384291009789952

Herbicidal properties of antihypertensive drugs: calcium channel blockers

Ejemplares similares