Mutational signatures are jointly shaped by DNA damage and repair

Recent research has shown that mutational signatures reflective of the history of a cancer can be detected in a cancer genome. Here, using whole genome sequencing of DNA repair deficient and proficient nematodes exposed to genotoxins, the authors show that these mutational signatures reflect both th...

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Autores principales:	Nadezda V. Volkova, Bettina Meier, Víctor González-Huici, Simone Bertolini, Santiago Gonzalez, Harald Vöhringer, Federico Abascal, Iñigo Martincorena, Peter J. Campbell, Anton Gartner, Moritz Gerstung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/586f62ed751f4d509ab638e75a89c6f7
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spelling	oai:doaj.org-article:586f62ed751f4d509ab638e75a89c6f72021-12-02T15:33:53ZMutational signatures are jointly shaped by DNA damage and repair10.1038/s41467-020-15912-72041-1723https://doaj.org/article/586f62ed751f4d509ab638e75a89c6f72020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15912-7https://doaj.org/toc/2041-1723Recent research has shown that mutational signatures reflective of the history of a cancer can be detected in a cancer genome. Here, using whole genome sequencing of DNA repair deficient and proficient nematodes exposed to genotoxins, the authors show that these mutational signatures reflect both the initial DNA damage that was inflicted and the repair processes that ensue.Nadezda V. VolkovaBettina MeierVíctor González-HuiciSimone BertoliniSantiago GonzalezHarald VöhringerFederico AbascalIñigo MartincorenaPeter J. CampbellAnton GartnerMoritz GerstungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadezda V. Volkova Bettina Meier Víctor González-Huici Simone Bertolini Santiago Gonzalez Harald Vöhringer Federico Abascal Iñigo Martincorena Peter J. Campbell Anton Gartner Moritz Gerstung Mutational signatures are jointly shaped by DNA damage and repair
description	Recent research has shown that mutational signatures reflective of the history of a cancer can be detected in a cancer genome. Here, using whole genome sequencing of DNA repair deficient and proficient nematodes exposed to genotoxins, the authors show that these mutational signatures reflect both the initial DNA damage that was inflicted and the repair processes that ensue.
format	article
author	Nadezda V. Volkova Bettina Meier Víctor González-Huici Simone Bertolini Santiago Gonzalez Harald Vöhringer Federico Abascal Iñigo Martincorena Peter J. Campbell Anton Gartner Moritz Gerstung
author_facet	Nadezda V. Volkova Bettina Meier Víctor González-Huici Simone Bertolini Santiago Gonzalez Harald Vöhringer Federico Abascal Iñigo Martincorena Peter J. Campbell Anton Gartner Moritz Gerstung
author_sort	Nadezda V. Volkova
title	Mutational signatures are jointly shaped by DNA damage and repair
title_short	Mutational signatures are jointly shaped by DNA damage and repair
title_full	Mutational signatures are jointly shaped by DNA damage and repair
title_fullStr	Mutational signatures are jointly shaped by DNA damage and repair
title_full_unstemmed	Mutational signatures are jointly shaped by DNA damage and repair
title_sort	mutational signatures are jointly shaped by dna damage and repair
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/586f62ed751f4d509ab638e75a89c6f7
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Mutational signatures are jointly shaped by DNA damage and repair

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