High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism

Abstract Dietary fiber functions as a prebiotic to determine the gut microbe composition. The gut microbiota influences the metabolic functions and immune responses in human health. The gut microbiota and metabolites produced by various dietary components not only modulate immunity but also impact v...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoon Ok Jang, Ock-Hwa Kim, Su Jung Kim, Se Hee Lee, Sunmi Yun, Se Eun Lim, Hyun Ju Yoo, Yong Shin, Sei Won Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5871397fac2249ffa57dc99e08d5a5f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5871397fac2249ffa57dc99e08d5a5f3
record_format	dspace
spelling	oai:doaj.org-article:5871397fac2249ffa57dc99e08d5a5f32021-12-02T11:45:01ZHigh-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism10.1038/s41598-021-86404-x2045-2322https://doaj.org/article/5871397fac2249ffa57dc99e08d5a5f32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86404-xhttps://doaj.org/toc/2045-2322Abstract Dietary fiber functions as a prebiotic to determine the gut microbe composition. The gut microbiota influences the metabolic functions and immune responses in human health. The gut microbiota and metabolites produced by various dietary components not only modulate immunity but also impact various organs. Although recent findings have suggested that microbial dysbiosis is associated with several respiratory diseases, including asthma, cystic fibrosis, and allergy, the role of microbiota and metabolites produced by dietary nutrients with respect to pulmonary disease remains unclear. Therefore, we explored whether the gut microbiota and metabolites produced by dietary fiber components could influence a cigarette smoking (CS)-exposed emphysema model. In this study, it was demonstrated that a high-fiber diet including non-fermentable cellulose and fermentable pectin attenuated the pathological changes associated with emphysema progression and the inflammatory response in CS-exposed emphysema mice. Moreover, we observed that different types of dietary fiber could modulate the diversity of gut microbiota and differentially impacted anabolism including the generation of short-chain fatty acids, bile acids, and sphingolipids. Overall, the results of this study indicate that high-fiber diets play a beneficial role in the gut microbiota-metabolite modulation and substantially affect CS-exposed emphysema mice. Furthermore, this study suggests the therapeutic potential of gut microbiota and metabolites from a high-fiber diet in emphysema via local and systemic inflammation inhibition, which may be useful in the development of a new COPD treatment plan.Yoon Ok JangOck-Hwa KimSu Jung KimSe Hee LeeSunmi YunSe Eun LimHyun Ju YooYong ShinSei Won LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoon Ok Jang Ock-Hwa Kim Su Jung Kim Se Hee Lee Sunmi Yun Se Eun Lim Hyun Ju Yoo Yong Shin Sei Won Lee High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
description	Abstract Dietary fiber functions as a prebiotic to determine the gut microbe composition. The gut microbiota influences the metabolic functions and immune responses in human health. The gut microbiota and metabolites produced by various dietary components not only modulate immunity but also impact various organs. Although recent findings have suggested that microbial dysbiosis is associated with several respiratory diseases, including asthma, cystic fibrosis, and allergy, the role of microbiota and metabolites produced by dietary nutrients with respect to pulmonary disease remains unclear. Therefore, we explored whether the gut microbiota and metabolites produced by dietary fiber components could influence a cigarette smoking (CS)-exposed emphysema model. In this study, it was demonstrated that a high-fiber diet including non-fermentable cellulose and fermentable pectin attenuated the pathological changes associated with emphysema progression and the inflammatory response in CS-exposed emphysema mice. Moreover, we observed that different types of dietary fiber could modulate the diversity of gut microbiota and differentially impacted anabolism including the generation of short-chain fatty acids, bile acids, and sphingolipids. Overall, the results of this study indicate that high-fiber diets play a beneficial role in the gut microbiota-metabolite modulation and substantially affect CS-exposed emphysema mice. Furthermore, this study suggests the therapeutic potential of gut microbiota and metabolites from a high-fiber diet in emphysema via local and systemic inflammation inhibition, which may be useful in the development of a new COPD treatment plan.
format	article
author	Yoon Ok Jang Ock-Hwa Kim Su Jung Kim Se Hee Lee Sunmi Yun Se Eun Lim Hyun Ju Yoo Yong Shin Sei Won Lee
author_facet	Yoon Ok Jang Ock-Hwa Kim Su Jung Kim Se Hee Lee Sunmi Yun Se Eun Lim Hyun Ju Yoo Yong Shin Sei Won Lee
author_sort	Yoon Ok Jang
title	High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
title_short	High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
title_full	High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
title_fullStr	High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
title_full_unstemmed	High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
title_sort	high-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5871397fac2249ffa57dc99e08d5a5f3
work_keys_str_mv	AT yoonokjang highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT ockhwakim highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT sujungkim highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT seheelee highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT sunmiyun highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT seeunlim highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT hyunjuyoo highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT yongshin highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism AT seiwonlee highfiberdietsattenuateemphysemadevelopmentviamodulationofgutmicrobiotaandmetabolism
_version_	1718395281939103744

High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism

Ejemplares similares