CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.

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Autores principales:	Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J. Adair, Stephen Shang, Alex D. Michaels, Matthew G. Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B. Stelow, P. Todd Stukenberg, J. Thomas Parsons, Todd W. Bauer, Mazhar Adli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5878576fa2b34029942f52a332a9c423
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spelling	oai:doaj.org-article:5878576fa2b34029942f52a332a9c4232021-12-02T15:33:57ZCRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response10.1038/s41467-018-06676-22041-1723https://doaj.org/article/5878576fa2b34029942f52a332a9c4232018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06676-2https://doaj.org/toc/2041-1723Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.Karol SzlachtaCem KuscuTuran TufanSara J. AdairStephen ShangAlex D. MichaelsMatthew G. MullenNatasha Lopes FischerJiekun YangLimin LiuPrasad TrivediEdward B. StelowP. Todd StukenbergJ. Thomas ParsonsTodd W. BauerMazhar AdliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karol Szlachta Cem Kuscu Turan Tufan Sara J. Adair Stephen Shang Alex D. Michaels Matthew G. Mullen Natasha Lopes Fischer Jiekun Yang Limin Liu Prasad Trivedi Edward B. Stelow P. Todd Stukenberg J. Thomas Parsons Todd W. Bauer Mazhar Adli CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
description	Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.
format	article
author	Karol Szlachta Cem Kuscu Turan Tufan Sara J. Adair Stephen Shang Alex D. Michaels Matthew G. Mullen Natasha Lopes Fischer Jiekun Yang Limin Liu Prasad Trivedi Edward B. Stelow P. Todd Stukenberg J. Thomas Parsons Todd W. Bauer Mazhar Adli
author_facet	Karol Szlachta Cem Kuscu Turan Tufan Sara J. Adair Stephen Shang Alex D. Michaels Matthew G. Mullen Natasha Lopes Fischer Jiekun Yang Limin Liu Prasad Trivedi Edward B. Stelow P. Todd Stukenberg J. Thomas Parsons Todd W. Bauer Mazhar Adli
author_sort	Karol Szlachta
title	CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
title_short	CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
title_full	CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
title_fullStr	CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
title_full_unstemmed	CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
title_sort	crispr knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5878576fa2b34029942f52a332a9c423
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CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

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