Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.

<h4>Background</h4>Coronary artery disease is very common in Pakistani population. Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by the ratio of concentrations of serum soluble transferrin receptor (sTfR) to ferrit...

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Autores principales:	Mohammad Perwaiz Iqbal, Naseema Mehboobali, Asal Khan Tareen, Mohsin Yakub, Saleem Perwaiz Iqbal, Khalida Iqbal, Ghulam Haider
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/587d0ee0bdc846d79a694172f827a8e2
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spelling	oai:doaj.org-article:587d0ee0bdc846d79a694172f827a8e22021-11-18T07:39:21ZAssociation of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.1932-620310.1371/journal.pone.0067981https://doaj.org/article/587d0ee0bdc846d79a694172f827a8e22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840800/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Coronary artery disease is very common in Pakistani population. Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by the ratio of concentrations of serum soluble transferrin receptor (sTfR) to ferritin and the risk of acute myocardial infarction (AMI). In order to investigate whether increased body iron status has any relationship with the risk of premature AMI in Pakistani population, a case-control study was carried out.<h4>Methodology/principal findings</h4>In this case-control study, 203 consecutive AMI patients [146 males and 57 females; age range 18-45 years] admitted to the National Institute for Cardiovascular Diseases, Karachi, were enrolled with informed consent. In addition, 205 healthy controls whose gender and age (within 3 years) matched the patients, and who had a similar socio-economic background were recruited. Fasting venous blood was obtained and assessed for plasma/serum folate, vitamin B12, homocysteine, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, sTfR and ferritin and blood lead. It was found that serum concentration of ferritin and blood lead levels were significantly higher in AMI patients compared to their age and gender-matched healthy controls (p value <0.05), while the concentrations of vitamin B12 and HDL-cholesterol were significantly lower in AMI patients compared to controls (p value <0.01). The ratio of sTfR to ferritin was significantly lower in AMI patients compared to controls [mean ± SD/median (IQR) values 84.7 ± 295/28.9 (38.4) vs 255 ± 836/49.4 (83.8), respectively; p value <0.001]. Compared with the highest quartile of sTfR/ferritin (low body iron status), the OR for the risk of AMI was 3.29(95% CI, 1.54-7.03) for the lowest quartile (quartile 1) when the model was adjusted for vitamin B12 and HDL-cholesterol (p value for trend <0.01).<h4>Conclusions/significance</h4>This study shows a positive association between total body iron status and risk of premature AMI in a Pakistani population.Mohammad Perwaiz IqbalNaseema MehboobaliAsal Khan TareenMohsin YakubSaleem Perwaiz IqbalKhalida IqbalGhulam HaiderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67981 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Perwaiz Iqbal Naseema Mehboobali Asal Khan Tareen Mohsin Yakub Saleem Perwaiz Iqbal Khalida Iqbal Ghulam Haider Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.
description	<h4>Background</h4>Coronary artery disease is very common in Pakistani population. Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by the ratio of concentrations of serum soluble transferrin receptor (sTfR) to ferritin and the risk of acute myocardial infarction (AMI). In order to investigate whether increased body iron status has any relationship with the risk of premature AMI in Pakistani population, a case-control study was carried out.<h4>Methodology/principal findings</h4>In this case-control study, 203 consecutive AMI patients [146 males and 57 females; age range 18-45 years] admitted to the National Institute for Cardiovascular Diseases, Karachi, were enrolled with informed consent. In addition, 205 healthy controls whose gender and age (within 3 years) matched the patients, and who had a similar socio-economic background were recruited. Fasting venous blood was obtained and assessed for plasma/serum folate, vitamin B12, homocysteine, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, sTfR and ferritin and blood lead. It was found that serum concentration of ferritin and blood lead levels were significantly higher in AMI patients compared to their age and gender-matched healthy controls (p value <0.05), while the concentrations of vitamin B12 and HDL-cholesterol were significantly lower in AMI patients compared to controls (p value <0.01). The ratio of sTfR to ferritin was significantly lower in AMI patients compared to controls [mean ± SD/median (IQR) values 84.7 ± 295/28.9 (38.4) vs 255 ± 836/49.4 (83.8), respectively; p value <0.001]. Compared with the highest quartile of sTfR/ferritin (low body iron status), the OR for the risk of AMI was 3.29(95% CI, 1.54-7.03) for the lowest quartile (quartile 1) when the model was adjusted for vitamin B12 and HDL-cholesterol (p value for trend <0.01).<h4>Conclusions/significance</h4>This study shows a positive association between total body iron status and risk of premature AMI in a Pakistani population.
format	article
author	Mohammad Perwaiz Iqbal Naseema Mehboobali Asal Khan Tareen Mohsin Yakub Saleem Perwaiz Iqbal Khalida Iqbal Ghulam Haider
author_facet	Mohammad Perwaiz Iqbal Naseema Mehboobali Asal Khan Tareen Mohsin Yakub Saleem Perwaiz Iqbal Khalida Iqbal Ghulam Haider
author_sort	Mohammad Perwaiz Iqbal
title	Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.
title_short	Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.
title_full	Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.
title_fullStr	Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.
title_full_unstemmed	Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.
title_sort	association of body iron status with the risk of premature acute myocardial infarction in a pakistani population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/587d0ee0bdc846d79a694172f827a8e2
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Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.

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