Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in gene...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Runxiang Qiu, Jun Wu, Brian Gudenas, Paul A. Northcott, Robert J. Wechsler-Reya, Qiang Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/587dca441c9e4d268442fa115aeff814
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:587dca441c9e4d268442fa115aeff814
record_format	dspace
spelling	oai:doaj.org-article:587dca441c9e4d268442fa115aeff8142021-12-02T14:35:46ZDepletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth10.1038/s42003-021-02075-42399-3642https://doaj.org/article/587dca441c9e4d268442fa115aeff8142021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02075-4https://doaj.org/toc/2399-3642Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in genetic and xenograft mouse models of medulloblastoma, indicating the value of targeting daughter cell fate specification.Runxiang QiuJun WuBrian GudenasPaul A. NorthcottRobert J. Wechsler-ReyaQiang LuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Runxiang Qiu Jun Wu Brian Gudenas Paul A. Northcott Robert J. Wechsler-Reya Qiang Lu Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
description	Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in genetic and xenograft mouse models of medulloblastoma, indicating the value of targeting daughter cell fate specification.
format	article
author	Runxiang Qiu Jun Wu Brian Gudenas Paul A. Northcott Robert J. Wechsler-Reya Qiang Lu
author_facet	Runxiang Qiu Jun Wu Brian Gudenas Paul A. Northcott Robert J. Wechsler-Reya Qiang Lu
author_sort	Runxiang Qiu
title	Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_short	Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_full	Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_fullStr	Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_full_unstemmed	Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_sort	depletion of kinesin motor kif20a to target cell fate control suppresses medulloblastoma tumour growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/587dca441c9e4d268442fa115aeff814
work_keys_str_mv	AT runxiangqiu depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth AT junwu depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth AT briangudenas depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth AT paulanorthcott depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth AT robertjwechslerreya depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth AT qianglu depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
_version_	1718391072079478784

Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

Ejemplares similares