Alzheimer's disease: analyzing the missing heritability.

Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide Complex Trait Analysis to analyze >2 million SNPs for 10,922 individuals from the Alzheimer's Disease Genetics Consort...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Perry G Ridge, Shubhabrata Mukherjee, Paul K Crane, John S K Kauwe, Alzheimer’s Disease Genetics Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/587e51c7b17945c7b0be9847d701f96c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:587e51c7b17945c7b0be9847d701f96c
record_format	dspace
spelling	oai:doaj.org-article:587e51c7b17945c7b0be9847d701f96c2021-11-18T08:47:52ZAlzheimer's disease: analyzing the missing heritability.1932-620310.1371/journal.pone.0079771https://doaj.org/article/587e51c7b17945c7b0be9847d701f96c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244562/?tool=EBIhttps://doaj.org/toc/1932-6203Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide Complex Trait Analysis to analyze >2 million SNPs for 10,922 individuals from the Alzheimer's Disease Genetics Consortium to assess the phenotypic variance explained first by known late-onset AD loci, and then by all SNPs in the Alzheimer's Disease Genetics Consortium dataset. In all, 33% of total phenotypic variance is explained by all common SNPs. APOE alone explained 6% and other known markers 2%, meaning more than 25% of phenotypic variance remains unexplained by known markers, but is tagged by common SNPs included on genotyping arrays or imputed with HapMap genotypes. Novel AD markers that explain large amounts of phenotypic variance are likely to be rare and unidentifiable using genome-wide association studies. Based on our findings and the current direction of human genetics research, we suggest specific study designs for future studies to identify the remaining heritability of Alzheimer's disease.Perry G RidgeShubhabrata MukherjeePaul K CraneJohn S K KauweAlzheimer’s Disease Genetics ConsortiumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79771 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Perry G Ridge Shubhabrata Mukherjee Paul K Crane John S K Kauwe Alzheimer’s Disease Genetics Consortium Alzheimer's disease: analyzing the missing heritability.
description	Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide Complex Trait Analysis to analyze >2 million SNPs for 10,922 individuals from the Alzheimer's Disease Genetics Consortium to assess the phenotypic variance explained first by known late-onset AD loci, and then by all SNPs in the Alzheimer's Disease Genetics Consortium dataset. In all, 33% of total phenotypic variance is explained by all common SNPs. APOE alone explained 6% and other known markers 2%, meaning more than 25% of phenotypic variance remains unexplained by known markers, but is tagged by common SNPs included on genotyping arrays or imputed with HapMap genotypes. Novel AD markers that explain large amounts of phenotypic variance are likely to be rare and unidentifiable using genome-wide association studies. Based on our findings and the current direction of human genetics research, we suggest specific study designs for future studies to identify the remaining heritability of Alzheimer's disease.
format	article
author	Perry G Ridge Shubhabrata Mukherjee Paul K Crane John S K Kauwe Alzheimer’s Disease Genetics Consortium
author_facet	Perry G Ridge Shubhabrata Mukherjee Paul K Crane John S K Kauwe Alzheimer’s Disease Genetics Consortium
author_sort	Perry G Ridge
title	Alzheimer's disease: analyzing the missing heritability.
title_short	Alzheimer's disease: analyzing the missing heritability.
title_full	Alzheimer's disease: analyzing the missing heritability.
title_fullStr	Alzheimer's disease: analyzing the missing heritability.
title_full_unstemmed	Alzheimer's disease: analyzing the missing heritability.
title_sort	alzheimer's disease: analyzing the missing heritability.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/587e51c7b17945c7b0be9847d701f96c
work_keys_str_mv	AT perrygridge alzheimersdiseaseanalyzingthemissingheritability AT shubhabratamukherjee alzheimersdiseaseanalyzingthemissingheritability AT paulkcrane alzheimersdiseaseanalyzingthemissingheritability AT johnskkauwe alzheimersdiseaseanalyzingthemissingheritability AT alzheimersdiseasegeneticsconsortium alzheimersdiseaseanalyzingthemissingheritability
_version_	1718421262225637376

Alzheimer's disease: analyzing the missing heritability.

Ejemplares similares