Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease

Keyu Yang, Xiaowei Zhang, Yong Zhou, Fu Chen, Mingyang Shen, Yong Wang Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaCorrespondence: Yong WangDepartment of General Surgery, Fourth Af...

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Autores principales:	Yang K, Zhang X, Zhou Y, Chen F, Shen M, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nesfatin-1 nafld bariatric surgery lsg Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/58849d9cfdd74ea18d6207a9e24ad19a
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spelling	oai:doaj.org-article:58849d9cfdd74ea18d6207a9e24ad19a2021-12-02T10:38:03ZChanges in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease1178-7007https://doaj.org/article/58849d9cfdd74ea18d6207a9e24ad19a2020-05-01T00:00:00Zhttps://www.dovepress.com/changes-in-serum-nesfatin-1-after-laparoscopic-sleeve-gastrectomy-are--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Keyu Yang, Xiaowei Zhang, Yong Zhou, Fu Chen, Mingyang Shen, Yong Wang Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaCorrespondence: Yong WangDepartment of General Surgery, Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan East Road, Huanggu District, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaTel +8618940259733Email wangyong@cmu.edu.cnBackground: Nonalcoholic fatty liver disease (NAFLD) is a serious and widespread disease worldwide. Bariatric surgery is one of the treatments for NAFLD. Nesfatin-1 is located in the brain, periphery and plasma. We studied the relationship between nesfatin-1 changes after laparoscopic sleeve gastrectomy (LSG) and NAFLD remission.Methods: A total of 29 patients participated in the study, which collected clinical information on the patients and indicators of liver function, hepatic steatosis score and nesfatin-1 level before and after LSG.Results: The average BMI of the patients before surgery was 42.63± 8.91 kg/m2, and the average BMI was 28.54± 5.63 kg/m2 one year after surgery (p <  0.05). One year after LSG, the total weight loss percentage (TWL%) was 32.11± 7.10%. The mean value of nesfatin-1 before surgery was 3.04± 0.81 ng/mL, and the mean value of nesfatin-1 was 5.52± 1.55 ng/mL at one year after surgery (p <  0.05). The average preoperative hepatic steatosis index (HSI) score of the patients was 52.55± 9.17, and the average postoperative HSI score was 38.84± 5.82 (p < 0.05). Before LSG (p < 0.05, r= − 0.81) and 1 year after surgery (p < 0.05, r = − 0.58), HSI and nesfatin-1 were significantly negatively correlated. Percentage of increased nesfatin-1 and percentage of decreased HSI showed positive correlation after LSG.Conclusion: There was a negative correlation between HSI and nesfatin-1 before and after LSG, which may suggest that nesfatin-1 plays a role in NAFLD.Keywords: nesfatin-1, NAFLD, bariatric surgery, LSGYang KZhang XZhou YChen FShen MWang YDove Medical Pressarticlenesfatin-1nafldbariatric surgerylsgSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1459-1464 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nesfatin-1 nafld bariatric surgery lsg Specialties of internal medicine RC581-951
spellingShingle	nesfatin-1 nafld bariatric surgery lsg Specialties of internal medicine RC581-951 Yang K Zhang X Zhou Y Chen F Shen M Wang Y Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
description	Keyu Yang, Xiaowei Zhang, Yong Zhou, Fu Chen, Mingyang Shen, Yong Wang Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaCorrespondence: Yong WangDepartment of General Surgery, Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan East Road, Huanggu District, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaTel +8618940259733Email wangyong@cmu.edu.cnBackground: Nonalcoholic fatty liver disease (NAFLD) is a serious and widespread disease worldwide. Bariatric surgery is one of the treatments for NAFLD. Nesfatin-1 is located in the brain, periphery and plasma. We studied the relationship between nesfatin-1 changes after laparoscopic sleeve gastrectomy (LSG) and NAFLD remission.Methods: A total of 29 patients participated in the study, which collected clinical information on the patients and indicators of liver function, hepatic steatosis score and nesfatin-1 level before and after LSG.Results: The average BMI of the patients before surgery was 42.63± 8.91 kg/m2, and the average BMI was 28.54± 5.63 kg/m2 one year after surgery (p <  0.05). One year after LSG, the total weight loss percentage (TWL%) was 32.11± 7.10%. The mean value of nesfatin-1 before surgery was 3.04± 0.81 ng/mL, and the mean value of nesfatin-1 was 5.52± 1.55 ng/mL at one year after surgery (p <  0.05). The average preoperative hepatic steatosis index (HSI) score of the patients was 52.55± 9.17, and the average postoperative HSI score was 38.84± 5.82 (p < 0.05). Before LSG (p < 0.05, r= − 0.81) and 1 year after surgery (p < 0.05, r = − 0.58), HSI and nesfatin-1 were significantly negatively correlated. Percentage of increased nesfatin-1 and percentage of decreased HSI showed positive correlation after LSG.Conclusion: There was a negative correlation between HSI and nesfatin-1 before and after LSG, which may suggest that nesfatin-1 plays a role in NAFLD.Keywords: nesfatin-1, NAFLD, bariatric surgery, LSG
format	article
author	Yang K Zhang X Zhou Y Chen F Shen M Wang Y
author_facet	Yang K Zhang X Zhou Y Chen F Shen M Wang Y
author_sort	Yang K
title	Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
title_short	Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
title_full	Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
title_fullStr	Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
title_full_unstemmed	Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
title_sort	changes in serum nesfatin-1 after laparoscopic sleeve gastrectomy are associated with improvements in nonalcoholic fatty liver disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/58849d9cfdd74ea18d6207a9e24ad19a
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Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease

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