Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation

Phase-separated condensates participate in various biological activities. Liquid–liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically disordered proteins. The manner in which chromatin—with various morphologies and activities—is organized in a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiaxiang Li, Jinmin Gao, Ruoxi Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	liquid-liquid phase separation (LLPS) chromosome organization mitosis meiosis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/58877a2fd59242e5b7a40482d7fcc0df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58877a2fd59242e5b7a40482d7fcc0df
record_format	dspace
spelling	oai:doaj.org-article:58877a2fd59242e5b7a40482d7fcc0df2021-11-25T17:54:54ZControl of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation10.3390/ijms2222122711422-00671661-6596https://doaj.org/article/58877a2fd59242e5b7a40482d7fcc0df2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12271https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Phase-separated condensates participate in various biological activities. Liquid–liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically disordered proteins. The manner in which chromatin—with various morphologies and activities—is organized in a complex and small nucleus still remains to be fully determined. Recent findings support the claim that phase separation is involved in the regulation of chromatin organization and chromosome behavior. Moreover, phase separation also influences key events during mitosis and meiosis. This review elaborately dissects how phase separation regulates chromatin and chromosome organization and controls mitotic and meiotic chromosome behavior.Jiaxiang LiJinmin GaoRuoxi WangMDPI AGarticleliquid-liquid phase separation (LLPS)chromosome organizationmitosismeiosisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12271, p 12271 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liquid-liquid phase separation (LLPS) chromosome organization mitosis meiosis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	liquid-liquid phase separation (LLPS) chromosome organization mitosis meiosis Biology (General) QH301-705.5 Chemistry QD1-999 Jiaxiang Li Jinmin Gao Ruoxi Wang Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
description	Phase-separated condensates participate in various biological activities. Liquid–liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically disordered proteins. The manner in which chromatin—with various morphologies and activities—is organized in a complex and small nucleus still remains to be fully determined. Recent findings support the claim that phase separation is involved in the regulation of chromatin organization and chromosome behavior. Moreover, phase separation also influences key events during mitosis and meiosis. This review elaborately dissects how phase separation regulates chromatin and chromosome organization and controls mitotic and meiotic chromosome behavior.
format	article
author	Jiaxiang Li Jinmin Gao Ruoxi Wang
author_facet	Jiaxiang Li Jinmin Gao Ruoxi Wang
author_sort	Jiaxiang Li
title	Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
title_short	Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
title_full	Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
title_fullStr	Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
title_full_unstemmed	Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
title_sort	control of chromatin organization and chromosome behavior during the cell cycle through phase separation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/58877a2fd59242e5b7a40482d7fcc0df
work_keys_str_mv	AT jiaxiangli controlofchromatinorganizationandchromosomebehaviorduringthecellcyclethroughphaseseparation AT jinmingao controlofchromatinorganizationandchromosomebehaviorduringthecellcyclethroughphaseseparation AT ruoxiwang controlofchromatinorganizationandchromosomebehaviorduringthecellcyclethroughphaseseparation
_version_	1718411861451341824

Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation

Ejemplares similares