Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts, whereby mutant p53-expressing cancer cells activat...

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Autores principales:	David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5887f05591104f9e9068f2413b7885fd
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spelling	oai:doaj.org-article:5887f05591104f9e9068f2413b7885fd2021-12-02T15:33:42ZMutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels10.1038/s41467-018-07339-y2041-1723https://doaj.org/article/5887f05591104f9e9068f2413b7885fd2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07339-yhttps://doaj.org/toc/2041-1723Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts, whereby mutant p53-expressing cancer cells activate an exosome-mediated mechanism that influences integrin recycling in fibroblasts, thus influencing extracellular matrix remodelling to favour cancer cell invasion and migration.David NovoNikki HeathLouise MitchellGiuseppina CaligiuriAmanda MacFarlaneDide ReijmerLaura CharltonJohn KnightMonika CalkaEwan McGheeEmmanuel DornierDavid SumptonSusan MasonArnaud EchardKerstin KlinkertJudith SecklehnerFlore KruiswijkKaren VousdenIain R. MacphersonKaren BlythPeter BaileyHuabing YinLeo M. CarlinJennifer MortonSara ZanivanJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Novo Nikki Heath Louise Mitchell Giuseppina Caligiuri Amanda MacFarlane Dide Reijmer Laura Charlton John Knight Monika Calka Ewan McGhee Emmanuel Dornier David Sumpton Susan Mason Arnaud Echard Kerstin Klinkert Judith Secklehner Flore Kruiswijk Karen Vousden Iain R. Macpherson Karen Blyth Peter Bailey Huabing Yin Leo M. Carlin Jennifer Morton Sara Zanivan Jim C. Norman Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
description	Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts, whereby mutant p53-expressing cancer cells activate an exosome-mediated mechanism that influences integrin recycling in fibroblasts, thus influencing extracellular matrix remodelling to favour cancer cell invasion and migration.
format	article
author	David Novo Nikki Heath Louise Mitchell Giuseppina Caligiuri Amanda MacFarlane Dide Reijmer Laura Charlton John Knight Monika Calka Ewan McGhee Emmanuel Dornier David Sumpton Susan Mason Arnaud Echard Kerstin Klinkert Judith Secklehner Flore Kruiswijk Karen Vousden Iain R. Macpherson Karen Blyth Peter Bailey Huabing Yin Leo M. Carlin Jennifer Morton Sara Zanivan Jim C. Norman
author_facet	David Novo Nikki Heath Louise Mitchell Giuseppina Caligiuri Amanda MacFarlane Dide Reijmer Laura Charlton John Knight Monika Calka Ewan McGhee Emmanuel Dornier David Sumpton Susan Mason Arnaud Echard Kerstin Klinkert Judith Secklehner Flore Kruiswijk Karen Vousden Iain R. Macpherson Karen Blyth Peter Bailey Huabing Yin Leo M. Carlin Jennifer Morton Sara Zanivan Jim C. Norman
author_sort	David Novo
title	Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
title_short	Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
title_full	Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
title_fullStr	Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
title_full_unstemmed	Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
title_sort	mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5887f05591104f9e9068f2413b7885fd
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Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

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