Microbial production of small peptide: pathway engineering and synthetic biology

Summary Small peptides are a group of natural products with low molecular weights and complex structures. The diverse structures of small peptides endow them with broad bioactivities and suggest their potential therapeutic use in the medical field. The remaining challenge is methods to address the m...

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Autores principales:	Zhiyong Wu, Youran Li, Liang Zhang, Zhongyang Ding, Guiyang Shi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/588a686a7b554f87920ee907a61f269c
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spelling	oai:doaj.org-article:588a686a7b554f87920ee907a61f269c2021-11-18T15:39:52ZMicrobial production of small peptide: pathway engineering and synthetic biology1751-791510.1111/1751-7915.13743https://doaj.org/article/588a686a7b554f87920ee907a61f269c2021-11-01T00:00:00Zhttps://doi.org/10.1111/1751-7915.13743https://doaj.org/toc/1751-7915Summary Small peptides are a group of natural products with low molecular weights and complex structures. The diverse structures of small peptides endow them with broad bioactivities and suggest their potential therapeutic use in the medical field. The remaining challenge is methods to address the main limitations, namely (i) the low amount of available small peptides from natural sources, and (ii) complex processes required for traditional chemical synthesis. Therefore, harnessing microbial cells as workhorse appears to be a promising approach to synthesize these bioactive peptides. As an emerging engineering technology, synthetic biology aims to create standard, well‐characterized and controllable synthetic systems for the biosynthesis of natural products. In this review, we describe the recent developments in the microbial production of small peptides. More importantly, synthetic biology approaches are considered for the production of small peptides, with an emphasis on chassis cells, the evolution of biosynthetic pathways, strain improvements and fermentation.Zhiyong WuYouran LiLiang ZhangZhongyang DingGuiyang ShiWileyarticleBiotechnologyTP248.13-248.65ENMicrobial Biotechnology, Vol 14, Iss 6, Pp 2257-2278 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65
spellingShingle	Biotechnology TP248.13-248.65 Zhiyong Wu Youran Li Liang Zhang Zhongyang Ding Guiyang Shi Microbial production of small peptide: pathway engineering and synthetic biology
description	Summary Small peptides are a group of natural products with low molecular weights and complex structures. The diverse structures of small peptides endow them with broad bioactivities and suggest their potential therapeutic use in the medical field. The remaining challenge is methods to address the main limitations, namely (i) the low amount of available small peptides from natural sources, and (ii) complex processes required for traditional chemical synthesis. Therefore, harnessing microbial cells as workhorse appears to be a promising approach to synthesize these bioactive peptides. As an emerging engineering technology, synthetic biology aims to create standard, well‐characterized and controllable synthetic systems for the biosynthesis of natural products. In this review, we describe the recent developments in the microbial production of small peptides. More importantly, synthetic biology approaches are considered for the production of small peptides, with an emphasis on chassis cells, the evolution of biosynthetic pathways, strain improvements and fermentation.
format	article
author	Zhiyong Wu Youran Li Liang Zhang Zhongyang Ding Guiyang Shi
author_facet	Zhiyong Wu Youran Li Liang Zhang Zhongyang Ding Guiyang Shi
author_sort	Zhiyong Wu
title	Microbial production of small peptide: pathway engineering and synthetic biology
title_short	Microbial production of small peptide: pathway engineering and synthetic biology
title_full	Microbial production of small peptide: pathway engineering and synthetic biology
title_fullStr	Microbial production of small peptide: pathway engineering and synthetic biology
title_full_unstemmed	Microbial production of small peptide: pathway engineering and synthetic biology
title_sort	microbial production of small peptide: pathway engineering and synthetic biology
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/588a686a7b554f87920ee907a61f269c
work_keys_str_mv	AT zhiyongwu microbialproductionofsmallpeptidepathwayengineeringandsyntheticbiology AT youranli microbialproductionofsmallpeptidepathwayengineeringandsyntheticbiology AT liangzhang microbialproductionofsmallpeptidepathwayengineeringandsyntheticbiology AT zhongyangding microbialproductionofsmallpeptidepathwayengineeringandsyntheticbiology AT guiyangshi microbialproductionofsmallpeptidepathwayengineeringandsyntheticbiology
_version_	1718420784061349888

Microbial production of small peptide: pathway engineering and synthetic biology

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