Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment. The most extensively studied Tie2 ligands are Angiopoietin 1 and 2 (Ang1, Ang2). Ang1...

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Autores principales:	Camille L. Duran, Lucia Borriello, George S. Karagiannis, David Entenberg, Maja H. Oktay, John S. Condeelis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Tie2 angiopoietin tumor microenvironment metastasis angiogenesis dissemination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/588da992d8954fada8ea576e145d5723
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spelling	oai:doaj.org-article:588da992d8954fada8ea576e145d57232021-11-25T17:03:21ZTargeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination10.3390/cancers132257302072-6694https://doaj.org/article/588da992d8954fada8ea576e145d57232021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5730https://doaj.org/toc/2072-6694The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment. The most extensively studied Tie2 ligands are Angiopoietin 1 and 2 (Ang1, Ang2). Ang1 plays a critical role in vessel maturation, endothelial cell migration, and survival. Ang2, depending on the context, may function to disrupt connections between the endothelial cells and perivascular cells, promoting vascular regression. However, in the presence of VEGF-A, Ang2 instead promotes angiogenesis. Tie2-expressing macrophages play a critical role in both tumor angiogenesis and the dissemination of tumor cells from the primary tumor to secondary sites. Therefore, Ang-Tie2 signaling functions as an angiogenic switch during tumor progression and metastasis. Here we review the recent advances and complexities of targeting Tie2 signaling in the tumor microenvironment as a possible anti-angiogenic, and anti-metastatic, therapy and describe its use in combination with chemotherapy.Camille L. DuranLucia BorrielloGeorge S. KaragiannisDavid EntenbergMaja H. OktayJohn S. CondeelisMDPI AGarticleTie2angiopoietintumor microenvironmentmetastasisangiogenesisdisseminationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5730, p 5730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tie2 angiopoietin tumor microenvironment metastasis angiogenesis dissemination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Tie2 angiopoietin tumor microenvironment metastasis angiogenesis dissemination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Camille L. Duran Lucia Borriello George S. Karagiannis David Entenberg Maja H. Oktay John S. Condeelis Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
description	The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment. The most extensively studied Tie2 ligands are Angiopoietin 1 and 2 (Ang1, Ang2). Ang1 plays a critical role in vessel maturation, endothelial cell migration, and survival. Ang2, depending on the context, may function to disrupt connections between the endothelial cells and perivascular cells, promoting vascular regression. However, in the presence of VEGF-A, Ang2 instead promotes angiogenesis. Tie2-expressing macrophages play a critical role in both tumor angiogenesis and the dissemination of tumor cells from the primary tumor to secondary sites. Therefore, Ang-Tie2 signaling functions as an angiogenic switch during tumor progression and metastasis. Here we review the recent advances and complexities of targeting Tie2 signaling in the tumor microenvironment as a possible anti-angiogenic, and anti-metastatic, therapy and describe its use in combination with chemotherapy.
format	article
author	Camille L. Duran Lucia Borriello George S. Karagiannis David Entenberg Maja H. Oktay John S. Condeelis
author_facet	Camille L. Duran Lucia Borriello George S. Karagiannis David Entenberg Maja H. Oktay John S. Condeelis
author_sort	Camille L. Duran
title	Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
title_short	Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
title_full	Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
title_fullStr	Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
title_full_unstemmed	Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
title_sort	targeting tie2 in the tumor microenvironment: from angiogenesis to dissemination
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/588da992d8954fada8ea576e145d5723
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Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

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